In their Grand Round,1 Louiselle LeBlanc and colleagues report an individual with neurosyphilis recurrence 5 months after optimal treatment for syphilitic myocarditis and neurosyphilis. We would like to suggest that the most probable explanation for th...
The rise in sexually transmitted infection (STI) rates over the last three years has renewed discussions about innovative approaches to prevention. Among these, doxycycline post-exposure prophylaxis (DoxyPEP) has emerged as a promising intervention.1 A...
The rise in sexually transmitted infection (STI) rates over the last three years has renewed discussions about innovative approaches to prevention. Among these, doxycycline post-exposure prophylaxis (DoxyPEP) has emerged as a promising intervention.1 A...
Influenza viruses have caused four pandemics during the last century.1 The 1918 H1N1 pandemic claimed 20–50 million lives, the 1957 H2N2 pandemic and the 1968 H3N2 pandemic claimed 1–4 million lives each, and the 2009 H1N1 pandemic claimed an estimated...
Whipple's disease is a chronic systemic bacterial infection. In most cases, intermittent migratory arthritis precedes the onset of other clinical manifestations of the disease by several years.1 Isolated forms are increasingly recognised. Before the ad...
Oral-only treatment of Whipple's disease was safe and non-inferior to sequential intravenous–oral treatment. Oral treatment facilitates patient management and might reduce hospital-acquired treatment complications and costs.
Candida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality. Candidaemia and other forms of invasive candidiasis primarily affect patients who are immunocompromis...
Respiratory syncytial virus (RSV) is known to cause considerable respiratory infection-related morbidity and mortality worldwide.1,2 Estimates published in 2022 from the UK highlight the disproportionate clinical effect of RSV infection in older people...
As the Trump administration shuts down the USA's main foreign-aid agency, USAID, the effects on global health are already being felt. Talha Burki reports.
On Jan 20, 2025, President Donald Trump signed an executive order withdrawing the USA from WHO, with wide-ranging ramifications for global health. Cahal McQuillan reports.
There are no approved treatments for post-COVID-19 condition (also known as long COVID), a debilitating disease state following SARS-CoV-2 infection that is estimated to affect tens of millions of people. A growing body of evidence shows that SARS-CoV-...
After the rapid spread of the SARS-CoV-2 JN.1 (BA.2.86.1.1) variant,1 several descendant lineages of JN.1, including KP.2 (JN.1.11.1.2),2 KP.3 (JN.1.11.1.3),2 and KP.3.1.1 (JN.1.11.1.3.1.1),3 have emerged and rapidly spread globally. Subsequently, XEC ...
The package of interventions consisting of pre-test and post-test tuberculosis counselling with conditional cash transfers significantly reduced the risk of unsuccessful tuberculosis patient outcomes, bringing one of the 90–90–90 targets within reach (...
In The Lancet Infectious Diseases, Nazir Ismail and colleagues1 report the findings of a randomised controlled trial done in South Africa, showing that a combination of pre-test and post-test tuberculosis counselling and electronic conditional cash tra...
At this point in time, with US President Trump's administration attacking institutions such as the US CDC, NIH, USAID, WHO, and their people and functions, whether science should be political seems like a rhetorical question. To us, the only logical an...
Marginalised populations often have reduced access to infectious disease prevention interventions, and as a result of this and other socioeconomic factors, these populations are at a higher risk of disease. Here, we reviewed the literature of community...