Complicated urinary tract infections denote an important research field for new antibiotics against Gram-negative pathogens. There is, however, increasing concern that this disease entity is too vaguely defined, leading to heterogeneous study populatio...
Cluster-randomised controlled trials (cRCTs) are considered the gold-standard design for testing urban mosquito control interventions.1 In The Lancet Infectious Diseases, Mitra Saadatian-Elahi and colleagues2 present the results of a large cRCT (280 cl...
Our study did not show an effect on the primary endpoint of the overall dengue incidence. Several factors such as substantial decrease in dengue incidence during the COVID-19 pandemic could have reduced the statistical power to detect significant diffe...
In their recent Review, Ramos and colleagues1 summarise the evolving landscape of pneumococcal disease and vaccines. However, two crucial issues warrant further discussion. First, many countries recommend adult pneumococcal vaccination using a risk-bas...
In this study, single-dose MoxA was superior to IA for W bancrofti microfilaria clearance at 12 months and provided prolonged microfilaria clearance for most participants. These results suggest that MoxA could be a powerful tool to accelerate the elimi...
Antimicrobial resistance (AMR) remains one of the most critical public health threats globally, and Ukraine is no exception. Even before the Russian full-scale invasion in 2022, Ukraine faced substantial challenges in controlling AMR.1 The ongoing war ...
These real-world estimates for the 2024 RSV season in Argentina show high RSVpreF effectiveness against RSV-associated LRTD and severe LRTD leading to hospitalisation from birth to age 3 months and sustained to age 6 months.
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract disease (LRTD), hospitalisation, and mortality in infants globally.1 Annually, RSV causes over 45 000 deaths, 1·4 million admissions to hospital, and 6·6 million LRTD ...
Growing pockets of undervaccination contribute to the resurgence and spread of infectious diseases, as shown by an ongoing measles outbreak in northwest Texas, USA.1 Measles is one of the most contagious diseases known to humans, with a basic reproduct...
Ensuring equitable access to effective antibiotics to treat drug-resistant infections is an essential component of the global response to antimicrobial resistance (AMR). In The Lancet Infectious Diseases, Anant Mishra and colleagues1 highlight the subs...
Dahmann S, Kueckelhaus M, Wiebringhaus P, et al. Maternal mastitis and streptococcal toxic shock syndrome risk from breastfeeding children with scarlet fever: case report and literature review. Lancet Infect Dis 2025; published online April 16. https:/...
Actinomycosis is a chronic bacterial infection caused by Actinomyces israelii, a Gram-positive anaerobic bacterium typically found in the oral cavity and gastrointestinal tract. This infection can present in various clinical and radiological forms, aff...
Infections caused by CRGN bacteria are likely to be significantly undertreated in LMICs. To close this treatment gap, improved access to diagnostics and antibiotics, strengthening of health systems, and research to identify gaps in the treatment pathwa...
Mensah and colleagues1 reported a 30% reduction (95% CI 18–40; p
These findings confirm previously observed safety and immunogenicity profiles of VLA15 in adults and extend them to children aged 5 years and older and adolescents. The greater immunogenicity of VLA15 among children and adolescents might translate to i...
Lyme borreliosis, known as Lyme disease in the USA, is the most common vector-borne disease in the temperate regions of the northern Hemisphere. It is caused by spirochetes of the Borrelia burgdorferi sensu lato complex and is transmitted by the bite o...