The coprimary endpoints were met, and NVX-CoV2601 was well tolerated. These interim data support NVX-CoV2601 use per guidance for XBB.1.5-directed COVID-19 vaccines and demonstrate the adaptability of this vaccine platform for updated SARS-CoV-2 spike ...
The cross-neutralising effects of COVID-19 vaccines given as prime–boost regimens have garnered much interest as SARS-CoV-2 has evolved. Several studies have shown that immunisation with heterologous vaccines, wherein the booster is based on a differen...
It became clear after the last call for malaria elimination in 2007 that Plasmodium vivax malaria would be a substantial bottleneck because of many evolutive advantages of this parasite, such as the early development of peripheral gametocytes and the d...
Substantial reductions in prevalence as measured by PCR were predicted with primaquine and tafenoquine regimens if these could be implemented with high coverage and adherence. The benefits of preventing P vivax relapses need to be balanced against the ...
Preventive chemotherapy with benzimidazole drugs (albendazole or mebendazole) is one main pillar of the WHO recommendations for the public health control of soil-transmitted helminthiases.1 In the past decade, the number of individuals receiving preven...
Treating a feverish planet: The Dengue Alliance is a short film released by Drugs for Neglected Diseases initiative (DNDi) on YouTube on Nov 7, 2024.
The foreign gaze: essays on global health, an open access book by Seye Abimbola, is a collection of essays that takes readers through the author's journey into global health, from Owo, a town in southwestern Nigeria, to his current position at Sydney U...
An FDC of albendazole plus ivermectin has a similar safety profile but superior efficacy to albendazole alone against T trichiura infection and hookworms. These findings open opportunities for control of all soil-transmitted helminth species of interes...
Imagine you are a beekeeper. As spring arrives and the air warms, the bees begin to wake up and search for food sources. One hive swarms and divides itself in two—one led by the old queen and her loyalists, the other by a new queen and a new order. Wit...
In southeast Senegal, a low-to-moderate transmission setting where malaria-control measures have been scaled up, three cycles of MDA with dihydroartemisinin–piperaquine plus single, low-dose primaquine was safe and reduced malaria burden during the int...
The idea of antimalarial mass drug administrations (MDA) arose in the early 20th century with the availability of effective and affordable drugs. When an entire community is treated at the same time, went the underlying hypothesis, humans stop infectin...
Shields RK, Abbo LM, Ackley R, et al. Effectiveness of ceftazidime–avibactam versus ceftolozanetazobactam for multidrug-resistant Pseudomonas aeruginosa infections in the USA (CACTUS): a multicentre, retrospective, observational study. Lancet Infect Di...
Despite the small sample size, our estimates provide evidence of effectiveness of a two-dose regimen against HEV genotype 1 during a protracted outbreak, supporting its use in similar contexts.
Hepatitis E virus (HEV), a leading cause of acute viral hepatitis globally, disproportionately impacts low-income countries through genotypes 1 and 2. These HEV genotypes, primarily transmitted via contaminated water and food, are associated with high ...
Multi-age cohort campaigns had a marked effect on vaccine-type carriage and fractional-dose campaigns met non-inferiority criteria. Such campaigns should be considered in low-coverage settings, including humanitarian emergencies, to accelerate populati...
Pneumococcal conjugate vaccines (PCVs) are highly effective but have a very low coverage (