Regeneration of Capto™ Core 700 resin through high throughput and laboratory scale studies and impact on production of a SARS-CoV-2 vaccine candidate

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

During the development of a SARS-CoV-2 vaccine candidate, at the height of the COVID-19 pandemic, raw materials shortages, including chromatography resins, necessitated the determination of a cleaning in place (CIP) strategy for a multimodal core-shell resin both rapidly and efficiently. Here, we describe the deployment of high throughput (HT) techniques to screen CIP conditions for cleaning Capto™ Core 700 resin exposed to clarified cell culture harvest of a SARS-CoV-2 vaccine candidate...

Relationship Between Optimism-Pessimism Levels of Mothers and Anxiety Levels of Children in Turkey During COVID-19 Pandemic

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

CONCLUSION: These findings suggest that mental health of children has been adversely affected during the pandemic and this has important implications for designing and implementing interventions aimed at reducing anxiety levels of children and determining protective and risk factors associated with anxiety in the face of adversity.

The nervous system during COVID-19: Caught in the crossfire<sup></sup>

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

SARS-CoV-2, the virus that causes coronavirus disease (COVID)-19, has become a persistent global health threat. Individuals who are symptomatic for COVID-19 frequently exhibit respiratory illness, which is often accompanied by neurological symptoms of anosmia and fatigue. Mounting clinical data also indicate that many COVID-19 patients display long-term neurological disorders postinfection such as cognitive decline, which emphasizes the need to further elucidate the effects of COVID-19 on the...

‘It was the worst possible timing’: the response of UK Longitudinal Integrated Clerkships to Covid-19

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

Covid-19 has altered medical education worldwide. Given recent events, UK Longitudinal Integrated Clerkships (LICs), which are relatively new innovations, may have changed in structure and delivery, or may have demonstrated resilience. Collating the responses and experiences of UK institutions may yield transferrable recommendations for institutions wishing to develop sustainable LICs. A mixed-methods survey concerning LIC prevalence, variety, and experiences of responses to Covid-19 was...

Chronological development of in-patient oncology in times of COVID-19: a retrospective analysis of hospitalized oncology and COVID-19 patients of a German University Hospital

Di |2022-06-30T00:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

CONCLUSION: The results confirm a decline in hospitalized oncology patients for the entire pandemic in the setting of a maximum care provider. Imposed lockdown and contact restrictions, rising COVID-19 case numbers, as well as discovery of new virus variants have a negative impact on hospitalized treated oncological patients.

Echocardiographic estimation of pulmonary hypertension in COVID-19 patients

Di |2022-06-30T00:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

CONCLUSION: eePH is frequently observed in COVID-19 patients and is correlated with increased mortality. COVID-19-related eePH appears to be reversible after recovery. Vigilant attention and a low threshold for performance of echocardiography in COVID-19 patients seems warranted, as eePH may be applicable as a prognostic risk factor.

Influences on PrEP Uptake and Adherence Among South African Women During Periconception and Pregnancy: A Qualitative Analysis

Di |2022-06-30T00:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

Pre-exposure prophylaxis (PrEP) is highly effective for HIV prevention, yet PrEP delivery to women in periconception and pregnancy has lagged. We report qualitative research from a study evaluating PrEP use as part of safer conception care for 330 South African women. Fifty-two semi-structured interviews were conducted with 25 study participants to identify influences on PrEP adherence. Influences were: (1) changing proximity to male partners; (2) COVID-19 lockdown; (3) mobile lifestyle; (4)...

Challenges and lessons in establishing human immune profiling cohort studies for pandemic response

Di |2022-06-30T00:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

Pandemics have devastating effects that can be mitigated with the existence of global infrastructure for pandemic preparedness along with the adaptation of existing research studies and establishment of biorepositories early in an outbreak. Observational cohort studies in place prior to a pandemic, that are rapidly scalable in response to emerging infectious diseases, are essential for both the early pandemic response and evaluation of its long-term effects. The ability to quickly collect and...

Organizing an in-person nation-wide Biology olympiad during the Covid-19 pandemic

Di |2022-06-30T00:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

The Covid-19 pandemic has inspired the implementation of a number of online educational activities designed to promote appropriate measures, such as social distancing, in order to avoid spread of the disease. In these circumstances, ensuring that extracurricular activities in science education adapt to the changing situation is of crucial importance. Recognizing the important role high school science olympiads play in science education, we organized an in-person socially distanced 2-day...

Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity

Di |2022-06-29T22:00:00+02:00Giugno 29th, 2022|Categorie: Coronavirus PubMed|

There is a pressing need for host-directed therapeutics that elicit broad-spectrum antiviral activities to potentially address current and future viral pandemics. Apratoxin S4 (Apra S4) is a potent Sec61 inhibitor that prevents cotranslational translocation of secretory proteins into the endoplasmic reticulum (ER), leading to anticancer and antiangiogenic activity both in vitro and in vivo. Since Sec61 has been shown to be an essential host factor for viral proteostasis, we tested Apra S4 in...

A Method for Variant Agnostic Detection of SARS-CoV-2, Rapid Monitoring of Circulating Variants, and Early Detection of Emergent Variants Such as Omicron

Di |2022-06-29T22:00:00+02:00Giugno 29th, 2022|Categorie: Coronavirus PubMed|

The rapid emergence of SARS-CoV-2 variants raised public health questions concerning the capability of diagnostic tests to detect new strains, the efficacy of vaccines, and how to map the geographical distribution of variants to understand transmission patterns and loads on healthcare resources. Next-generation sequencing (NGS) is the primary method for detecting and tracing new variants, but it is expensive, and it can take weeks before sequence data are available in public repositories. This...

Maternal and Neonatal Outcomes in Pregnant Women With SARS-CoV-2 Infection Complicated by Hepatic Dysfunction

Di |2022-06-28T15:00:00+02:00Giugno 28th, 2022|Categorie: Coronavirus PubMed|

Background and objective The coronavirus disease 2019 (COVID-19) pandemic has caused one of the most devastating healthcare crises in recent times and presented many diagnostic challenges and uncertainties. COVID-19 complicated by acute hepatic dysfunction is a well-described phenomenon, but its impact on maternal and perinatal outcomes is not well documented. In this study, we aimed to evaluate the maternal and neonatal outcomes in pregnant women with COVID-19 complicated by liver dysfunction...

Acute SARS-CoV-2-Induced Psychosis in an Adolescents

Di |2022-06-28T15:00:00+02:00Giugno 28th, 2022|Categorie: Coronavirus PubMed|

Severe SARS-CoV-2COVID-19 illness in pediatrics is less common in children than in adults. Here we report an unvaccinated 16-year-old male, normally fit and well with no previous personal or family history of mental illness who developed moderate respiratory illness related to SARS-CoV-2 infection that was followed by acute psychosis. Neuropsychiatric manifestations are well documented in adults with SARS-CoV-2 infections; however, there are few reports in the pediatric population. This case...

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