Immunomodulatory and Antiviral Activity of Metformin and Its Potential Implications in Treating Coronavirus Disease 2019 and Lung Injury

By |2020-09-25T12:00:00+02:00September 25th, 2020|Categories: Coronavirus PubMed|

The pandemic of coronavirus disease 2019 (COVID-19), a disease which causes severe lung injury and multiple organ damage, presents an urgent need for new drugs. The case severity and fatality of COVID-19 are associated with excessive inflammation, namely, a cytokine storm. Metformin, a widely used drug to treat type 2 diabetes (T2D) mellitus and metabolic syndrome, has immunomodulatory activity that reduces the production of proinflammatory cytokines using macrophages and causes the formation of...

Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider

By |2020-09-25T12:00:00+02:00September 25th, 2020|Categories: Coronavirus PubMed|

COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as the most life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described as regulator of both processes. Hereby, we present compelling evidences on the potential role of galectin-3 in COVID-19 in the regulation of the...

The role of public-private partnerships in extending public healthcare provision to irregular migrants: stopgap or foot in the door?

By |2020-09-25T12:00:00+02:00September 25th, 2020|Categories: Coronavirus PubMed|

In this commentary to the paper "Ensuring HIV care to undocumented migrants in Israel: a public-private partnership case study" by Chemtob et al. we discuss the role of public-private partnerships (PPPs) as a mechanism for integrating previously excluded groups in public healthcare provision. Drawing on PPP case-studies as well as on Israel's pandemic preparedness policies during the Covid-19 outbreak, we examine potential implications for the populations in question and for health systems.In...

Acute Ischemic Stroke and COVID-19: Experience From a Comprehensive Stroke Center in Midwest US

By |2020-09-25T12:00:00+02:00September 25th, 2020|Categories: Coronavirus PubMed|

Background: COVID-19 has been associated with increased risk of venous and arterial thromboembolism including ischemic stroke. We report on patients with acute ischemic stroke and concomitant COVID-19 in a diverse patient population. Methods: This is a retrospective analysis of patients hospitalized with acute ischemic stroke (AIS) and COVID-19 to our comprehensive stroke center in Chicago, IL, between March 1, 2020, and April 30, 2020. We reviewed stroke characteristics, etiologies, and...

Similarities and Differences of Early Pulmonary CT Features of Pneumonia Caused by SARS-CoV-2, SARS-CoV and MERS-CoV: Comparison Based on a Systemic Review

By |2020-09-25T12:00:00+02:00September 25th, 2020|Categories: Coronavirus PubMed|

Objective To compare the similarities and differences of early CT manifestations of three types of viral pneumonia induced by SARS-CoV-2 (COVID-19), SARS-CoV (SARS) and MERS-CoV (MERS) using a systemic review. Methods Electronic database were searched to identify all original articles and case reports presenting chest CT features for adult patients with COVID-19, SARS and MERS pneumonia respectively. Quality of literature and completeness of presented data were evaluated by consensus reached by...

Mucormycosis with orbital compartment syndrome in a patient with COVID-19

By |2020-09-25T12:00:00+02:00September 25th, 2020|Categories: Coronavirus PubMed|

During the current pandemic of COVID-19, a myriad of manifestations and complications has emerged and are being reported on. We are discovering patients with COVID-19 are at increased risk of acute cardiac injury, arrythmias, thromboembolic complications (pulmonary embolism and acute stroke), and secondary infection to name a few. I describe a novel case of COVID-19 in a previously healthy 33-year-old female who presented for altered mental status and proptosis. She was ultimately diagnosed with...

Minimal Change Disease With Nephrotic Syndrome Associated With Coronavirus Disease 2019 After Apolipoprotein L1 Risk Variant Kidney Transplant: A Case Report

By |2020-09-25T12:00:00+02:00September 25th, 2020|Categories: Coronavirus PubMed|

Kidney injury is a well-known complication in people with coronavirus disease 2019 (COVID-19). In kidney transplant recipients with COVID-19, presentation with nephrotic syndrome has not been well described. We report on a 49-year-old black female kidney transplant recipient who presented 25 years after transplant with clinical features of nephrotic syndrome following a diagnosis of COVID-19. Histologic examination showed acute tubular injury with unremarkable glomeruli on light microscopy and...

Unveiling COVID-19 from CHEST X-Ray with Deep Learning: A Hurdles Race with Small Data

By |2020-09-25T12:00:00+02:00September 25th, 2020|Categories: Coronavirus PubMed|

The possibility to use widespread and simple chest X-ray (CXR) imaging for early screening of COVID-19 patients is attracting much interest from both the clinical and the AI community. In this study we provide insights and also raise warnings on what is reasonable to expect by applying deep learning to COVID classification of CXR images. We provide a methodological guide and critical reading of an extensive set of statistical results that can be obtained using currently available datasets. In...

Antibiotic potentiation of natural products: A promising target to fight pathogenic bacteria

By |2020-09-25T12:00:00+02:00September 25th, 2020|Categories: Coronavirus PubMed|

Pathogenic microorganisms should be considered as human number one foe as witnessed by recent outbreaks of coronavirus disease (COVID-19) and with bacteria no longer sensitive to existing antibiotics. The resistance of pathogenic bacteria and deaths attributable to bacterial infections is increasing exponentially. Bacteria used different mechanisms to counterattack to existing antibiotics namely (i) enzymatic inhibition, (ii) penicillin binding protein modification, (iii) porin mutations, (iv)...

Mesenchymal stem cell research progress for the treatment of COVID-19

By |2020-09-25T12:00:00+02:00September 25th, 2020|Categories: Coronavirus PubMed|

At the end of 2019, novel coronavirus (COVID-19) infection was detected in Wuhan City, Hubei Province, China. The COVID-19 infection characteristics include a long incubation period, strong infectivity, and high fatality rate, and it negatively affects human health and social development. COVID-19 has become a common problem in the global medical and health system. It is essentially an acute self-limiting disease. Patients with severe COVID-19 infection usually progress to acute respiratory...

Rapid Selective Detection of Potentially Infectious Porcine Epidemic Diarrhea Coronavirus Exposed to Heat Treatments Using Viability RT-qPCR

By |2020-09-25T12:00:00+02:00September 25th, 2020|Categories: Coronavirus PubMed|

Coronaviruses (CoVs) cause severe respiratory, enteric, and systemic infections in a wide range of hosts, including humans and animals. Porcine epidemic diarrhea virus (PEDV), a member of the Coronaviridae family, is the etiological agent of porcine epidemic diarrhea (PED), a highly contagious intestinal disease affecting pigs of all ages. In this study, we optimized a viability real-time reverse transcriptase polymerase chain reaction (RT-qPCR) for the selective detection of infectious and...

Probiotics at War Against Viruses: What Is Missing From the Picture?

By |2020-09-25T12:00:00+02:00September 25th, 2020|Categories: Coronavirus PubMed|

Our world is now facing a multitude of novel infectious diseases. Bacterial infections are treated with antibiotics, albeit with increasing difficulty as many of the more common causes of infection have now developed broad spectrum antimicrobial resistance. However, there is now an even greater challenge from both old and new viruses capable of causing respiratory, enteric, and urogenital infections. Reports of viruses resistant to frontline therapeutic drugs are steadily increasing and there is...

The 2020 Pandemic: Current SARS-CoV-2 Vaccine Development

By |2020-09-25T12:00:00+02:00September 25th, 2020|Categories: Coronavirus PubMed|

Coronaviruses are enveloped viruses with a positive-sense single-stranded RNA genome infecting animals and humans. Coronaviruses have been described more than 70 years ago and contain many species. Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are lethal species caused by human coronaviruses (HCoVs). Currently, a novel strain of HCoVs, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (Covid-19). SARS-CoV-2...

The Strengths of Scanning Electron Microscopy in Deciphering SARS-CoV-2 Infectious Cycle

By |2020-09-25T12:00:00+02:00September 25th, 2020|Categories: Coronavirus PubMed|

Electron microscopy is a powerful tool in the field of microbiology. It has played a key role in the rapid diagnosis of viruses in patient samples and has contributed significantly to the clarification of virus structure and function, helping to guide the public health response to emerging viral infections. In the present study, we used scanning electron microscopy (SEM) to study the infectious cycle of SARS-CoV-2 in Vero E6 cells and we controlled some key findings by classical transmission...