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Vasoactive intestinal peptide: a potential target for antiviral therapy

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

Viral infection is clinically common and some viral diseases, such as the ongoing global outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), have high morbidity and mortality. However, most viral infections are currently lacking in specific therapeutic agents and effective prophylactic vaccines, due to inadequate response, increased rate of drug resistance and severe adverse side effects. Therefore, it is urgent to find new...

Spatially Patterned Neutralizing Icosahedral DNA Nanocage for Efficient SARS-CoV-2 Blocking

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

Broad-spectrum anti-SARS-CoV-2 strategies that can inhibit the infection of wild-type and mutant strains would alleviate their threats to global public health. Here, we propose an icosahedral DNA framework for the assembly of up to 30 spatially arranged neutralizing aptamers (IDNA-30) to inhibit viral infection. Each triangular plane of IDNA-30 is composed of three precisely positioned aptamers topologically matching the SARS-CoV-2 spike trimer, thus forming a multivalent spatially patterned...

Insights on the Quantitative Concurrent Fluorescence-Based Analysis of Anti-COVID-19 Drugs Remdesivir and Favipiravir

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

We hereby introduce a sensitive fast straightforward spectrofluorometric method for the estimation of remdesivir and favipiravir. The two drugs are prescribed in some regimens to treat COVID-19 pandemic disease, which is caused by SARS-CoV-2. The method is based on the first derivative synchronous spectrofluorimetry approach for the measurement of remdesivir and favipiravir. This was accomplished at 251 nm and 335 nm respectively using the first derivative order at delta lambda of 140 nm. A...

Antibody response to BNT162b2 mRNA vaccine in gingival crevicular fluid

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

CONCLUSION: This study establishes GCF and saliva as viable alternative non-invasive sources to monitor levels of antibodies following vaccination, with GCF demonstrating feasibility as a biofluid source for the detection of antibodies against SARS-CoV-2 S1-RBD antigen. This article is protected by copyright. All rights reserved.

Interleukin-6 blocking therapy for COVID-19: From immune pathogenesis to clinical outcomes

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

As a newly emerged infectious disease, the coronavirus disease 2019 (COVID-19) has caused millions of deaths, resulting in a global health challenge. Currently, several vaccines have been approved with significant benefits against disease transmission. However, effective therapies are still needed for the clinical management of infected COVID-19 patients. Available evidence has indicated elevated levels of proinflammatory cytokines, including interleukin-6 (IL-6), in COVID-19 patients, with...

IMM-BCP-01, a patient-derived anti-SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

Monoclonal antibodies are an efficacious therapy against SARS-CoV-2. However, rapid viral mutagenesis, led to escape from most of these therapies, outlining the need for an antibody cocktail with a broad neutralizing potency. Using an unbiased interrogation of the memory B cell repertoire of convalescent COVID-19 patients, we identified human antibodies with broad antiviral activity in vitro and efficacy in vivo against all tested SARS-CoV-2 variants of concern, including Delta, Omicron BA.1 and...

Projecting the SARS-CoV-2 transition from pandemicity to endemicity: Epidemiological and immunological considerations

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

In this review, we discuss the epidemiological dynamics of different viral infections to project how the transition from a pandemic to endemic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) might take shape. Drawing from theories of disease invasion and transmission dynamics, waning immunity in the face of viral evolution and antigenic drift, and empirical data from influenza, dengue, and seasonal coronaviruses, we discuss the putative periodicity, severity, and age dynamics of...

Interim Recommendations of the Advisory Committee on Immunization Practices for Use of Moderna and Pfizer-BioNTech COVID-19 Vaccines in Children Aged 6 Months-5 Years – United States, June 2022

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

On June 17, 2022, the Food and Drug Administration (FDA) issued Emergency Use Authorization (EUA) amendments for the mRNA-1273 (Moderna) COVID-19 vaccine for use in children aged 6 months-5 years, administered as 2 doses (25 µg [0.25 mL] each), 4 weeks apart, and BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine for use in children aged 6 months-4 years, administered as 3 doses (3 µg [0.2 mL] each), at intervals of 3 weeks between doses 1 and 2 and ≥8 weeks between doses 2 and 3. On June 18, 2022, the...

Ab-CoV: a curated database for binding affinity and neutralization profiles of coronavirus related antibodies

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

SUMMARY: We have developed a database, Ab-CoV, which contains manually curated experimental interaction profiles of 1780 coronavirus related neutralizing antibodies. It contains more than 3200 datapoints on half maximal inhibitory concentration (IC50), half maximal effective concentration (EC50) and binding affinity (KD). Each data with experimentally known three-dimensional structures are complemented with predicted change in stability and affinity of all possible point mutations of interface...

Mental Health amid COVID-19 Pandemic: Appropriate Coping Strategies

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

COVID-19 is a global public health crisis, and is turning to be a major mental health problem. This review provides a broad overview of mental health situations during COVID-19 pandemic in Africa and globally, while some preventive methods to improve mental health conditions during the pandemic were provided. In the Africa context, various government authorities must ensure the provision and accessibility to mental health care services such as routine preventive information, mental health...

The Rising Scourge of Mental Illness and Infodemic: An Outcome of Social Media and COVID-19

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

COVID-19 was accompanied with the increasing broadcast of fake news, misinformation and excessive information via social media platforms. This phenomenon has been termed "infodemic", to describe an overwhelming amount of mostly fake, false or inaccurate information which spreads rapidly and impacts negatively on achieving a solution. It would therefore be desirable to use a cautious approach which utilizes culturally sensitive and country specific measures to deal with this occurrence. We aim to...

Death anxiety and satisfaction with life among the adults in the social isolation process of Covid-19 pandemic: the mediating role of perceived stress

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

CONCLUSIONS: The findings of the study contributed to the structuring of psychological health services to be offered within the scope of public health during the Covid-19 pandemic and the understanding of the complex nature of the relationship between psychological factors and satisfaction with life. Possible explanations and limitations were discussed.

Coronavirus and Paramyxovirus Shedding by Bats in a Cave and Buildings in Ethiopia

Di |2022-06-30T01:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus PubMed|

Bats are important hosts of zoonotic viruses with pandemic potential, including filoviruses, MERS-Coronavirus (CoV), SARS-CoV -1, and likely SARS-CoV-2. Viral infection and transmission among wildlife are dependent on a combination of factors that include host ecology and immunology, life history traits, roosting habitats, biogeography, and external stressors. Between 2016 and 2018, four species of insectivorous bats from a readily accessed roadside cave and buildings in Ethiopia were sampled...

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