The global morbidity, mortality, and societal disruption caused by the coronavirus disease 2019 (Covid-19) pandemic prompted accelerated clinical vaccine development and regulatory interventions to mitigate some of its consequences. Between December 20...
The coronavirus disease 2019 (Covid-19) pandemic continues, with recent estimates of more than 187 million cases diagnosed and more than 4 million deaths. Vaccines are currently available by means of full approval, conditional marketing approval, and e...
To the Editor: Vaccine-induced immune thrombotic thrombocytopenia (VITT) has been described after vaccination with the adenoviral vector vaccines ChAdOx1 nCoV-19 (Oxford–AstraZeneca) and Ad26.COV2.S (Johnson & Johnson–Janssen). VITT is caused by pl...
To the Editor: In a small group of recipients of messenger RNA (mRNA) vaccines against coronavirus disease 2019 (Covid-19), the occurrence of erythematous and indurated skin reactions has been reported at an average of 8 days after the first or second ...
To the Editor: Whether vaccination of individual persons for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protects members of their households is unclear. We investigated the effect of vaccination of health care workers in Scotland (who...
As of June 6, 2021, approximately 175 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and 3.8 million deaths from coronavirus disease 2019 (Covid-19) have been reported worldwide. Programs providing unprecedented rapid c...
To the Editor: We conducted a global, randomized, placebo-controlled, phase 1–2–3 pivotal trial in which two 30-μg doses of BNT162b2 (Pfizer–BioNTech) were administered 21 days apart (ClinicalTrials.gov number, NCT04368728). These doses of vaccine had ...
Before my son left home on the first day of school, I took his photo — attempting, like generations of parents before me, to hit the "pause" button on life for a few seconds, capturing the start of a new chapter of childhood. The photo contained 5 year...
The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at t...
To the Editor: Pregnant women with coronavirus disease 2019 (Covid-19) are at increased risk for adverse outcomes, and Covid-19 vaccination is recommended during pregnancy. However, safety data on Covid-19 vaccination during pregnancy remain limited. W...
To the Editor: The mRNA vaccines have been shown to be highly effective in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and associated illness, although recent reports suggest reduced effectiveness against infection...
To the Editor: The B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as the dominant strain circulating in many regions worldwide. The BNT162b2 mRNA vaccine against coronavirus disease 2019 (Covid-19)...
To the Editor: Ivermectin is approved by the Food and Drug Administration as an oral treatment for intestinal strongyloidiasis and onchocerciasis and as a topical treatment for pediculosis and rosacea. It is also used as a treatment for parasites in pe...