Decline in Pathogenic Antibodies over Time in VITT [language] = "en-us"

Di |2021-11-04T23:00:00+01:00Novembre 4th, 2021|Categorie: Coronavirus NEJM|

To the Editor: Vaccine-induced immune thrombotic thrombocytopenia (VITT) has been described after vaccination with the adenoviral vector vaccines ChAdOx1 nCoV-19 (Oxford–AstraZeneca) and Ad26.COV2.S (Johnson & Johnson–Janssen). VITT is caused by pl...

Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase [language] = "en-us"

Di |2021-11-04T23:00:00+01:00Novembre 4th, 2021|Categorie: Coronavirus NEJM|

The global morbidity, mortality, and societal disruption caused by the coronavirus disease 2019 (Covid-19) pandemic prompted accelerated clinical vaccine development and regulatory interventions to mitigate some of its consequences. Between December 20...

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months [language] = "en-us"

Di |2021-11-04T23:00:00+01:00Novembre 4th, 2021|Categorie: Coronavirus NEJM|

The coronavirus disease 2019 (Covid-19) pandemic continues, with recent estimates of more than 187 million cases diagnosed and more than 4 million deaths. Vaccines are currently available by means of full approval, conditional marketing approval, and e...

Rare Skin Reactions after mRNA Vaccination, Similar to Jones–Mote Basophil Responses [language] = "en-us"

Di |2021-10-28T23:00:00+02:00Ottobre 28th, 2021|Categorie: Coronavirus NEJM|

To the Editor: In a small group of recipients of messenger RNA (mRNA) vaccines against coronavirus disease 2019 (Covid-19), the occurrence of erythematous and indurated skin reactions has been reported at an average of 8 days after the first or second ...

Effect of Vaccination on Transmission of SARS-CoV-2 [language] = "en-us"

Di |2021-10-28T23:00:00+02:00Ottobre 28th, 2021|Categorie: Coronavirus NEJM|

To the Editor: Whether vaccination of individual persons for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protects members of their households is unclear. We investigated the effect of vaccination of health care workers in Scotland (who...

Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis [language] = "en-us"

Di |2021-10-28T23:00:00+02:00Ottobre 28th, 2021|Categorie: Coronavirus NEJM|

As of June 6, 2021, approximately 175 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and 3.8 million deaths from coronavirus disease 2019 (Covid-19) have been reported worldwide. Programs providing unprecedented rapid c...

SARS-CoV-2 Neutralization with BNT162b2 Vaccine Dose 3 [language] = "en-us"

Di |2021-10-21T23:00:00+02:00Ottobre 21st, 2021|Categorie: Coronavirus NEJM|

To the Editor: We conducted a global, randomized, placebo-controlled, phase 1–2–3 pivotal trial in which two 30-μg doses of BNT162b2 (Pfizer–BioNTech) were administered 21 days apart (ClinicalTrials.gov number, NCT04368728). These doses of vaccine had ...

Peak Moments — When Kindergarten Is High Risk [language] = "en-us"

Di |2021-10-21T23:00:00+02:00Ottobre 21st, 2021|Categorie: Coronavirus NEJM|

Before my son left home on the first day of school, I took his photo — attempting, like generations of parents before me, to hit the "pause" button on life for a few seconds, capturing the start of a new chapter of childhood. The photo contained 5 year...

Audio Interview: A New Look at Covid-19 Vaccine Boosters [language] = "en-us"

Di |2021-10-21T23:00:00+02:00Ottobre 21st, 2021|Categorie: Coronavirus NEJM|

The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at t...

Covid-19 Vaccination during Pregnancy and First-Trimester Miscarriage [language] = "en-us"

Di |2021-10-20T23:00:00+02:00Ottobre 20th, 2021|Categorie: Coronavirus NEJM|

To the Editor: Pregnant women with coronavirus disease 2019 (Covid-19) are at increased risk for adverse outcomes, and Covid-19 vaccination is recommended during pregnancy. However, safety data on Covid-19 vaccination during pregnancy remain limited. W...

Effectiveness of the mRNA-1273 Vaccine during a SARS-CoV-2 Delta Outbreak in a Prison [language] = "en-us"

Di |2021-10-20T23:00:00+02:00Ottobre 20th, 2021|Categorie: Coronavirus NEJM|

To the Editor: The mRNA vaccines have been shown to be highly effective in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and associated illness, although recent reports suggest reduced effectiveness against infection...

Effectiveness of BNT162b2 Vaccine against Delta Variant in Adolescents [language] = "en-us"

Di |2021-10-20T23:00:00+02:00Ottobre 20th, 2021|Categorie: Coronavirus NEJM|

To the Editor: The B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as the dominant strain circulating in many regions worldwide. The BNT162b2 mRNA vaccine against coronavirus disease 2019 (Covid-19)...

Toxic Effects from Ivermectin Use Associated with Prevention and Treatment of Covid-19 [language] = "en-us"

Di |2021-10-20T23:00:00+02:00Ottobre 20th, 2021|Categorie: Coronavirus NEJM|

To the Editor: Ivermectin is approved by the Food and Drug Administration as an oral treatment for intestinal strongyloidiasis and onchocerciasis and as a topical treatment for pediculosis and rosacea. It is also used as a treatment for parasites in pe...

Data in Crisis — Rethinking Disaster Preparedness in the United States [language] = "en-us"

Di |2021-10-14T23:00:00+02:00Ottobre 14th, 2021|Categorie: Coronavirus NEJM|

In 2017, Hurricane Maria’s devastating impact in Puerto Rico exposed significant flaws in the U.S. medical and public health response to natural disasters. The majority of the nearly 3000 excess deaths caused by the hurricane were attributable not to i...

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