Decline in Pathogenic Antibodies over Time in VITT [language] = "en-us"

Di |2021-11-04T23:00:00+01:00Novembre 4th, 2021|Categorie: Coronavirus NEJM|

To the Editor: Vaccine-induced immune thrombotic thrombocytopenia (VITT) has been described after vaccination with the adenoviral vector vaccines ChAdOx1 nCoV-19 (Oxford–AstraZeneca) and Ad26.COV2.S (Johnson & Johnson–Janssen). VITT is caused by pl...

Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase [language] = "en-us"

Di |2021-11-04T23:00:00+01:00Novembre 4th, 2021|Categorie: Coronavirus NEJM|

The global morbidity, mortality, and societal disruption caused by the coronavirus disease 2019 (Covid-19) pandemic prompted accelerated clinical vaccine development and regulatory interventions to mitigate some of its consequences. Between December 20...

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months [language] = "en-us"

Di |2021-11-04T23:00:00+01:00Novembre 4th, 2021|Categorie: Coronavirus NEJM|

The coronavirus disease 2019 (Covid-19) pandemic continues, with recent estimates of more than 187 million cases diagnosed and more than 4 million deaths. Vaccines are currently available by means of full approval, conditional marketing approval, and e...

Rare Skin Reactions after mRNA Vaccination, Similar to Jones–Mote Basophil Responses [language] = "en-us"

Di |2021-10-28T23:00:00+02:00Ottobre 28th, 2021|Categorie: Coronavirus NEJM|

To the Editor: In a small group of recipients of messenger RNA (mRNA) vaccines against coronavirus disease 2019 (Covid-19), the occurrence of erythematous and indurated skin reactions has been reported at an average of 8 days after the first or second ...

Effect of Vaccination on Transmission of SARS-CoV-2 [language] = "en-us"

Di |2021-10-28T23:00:00+02:00Ottobre 28th, 2021|Categorie: Coronavirus NEJM|

To the Editor: Whether vaccination of individual persons for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protects members of their households is unclear. We investigated the effect of vaccination of health care workers in Scotland (who...

Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis [language] = "en-us"

Di |2021-10-28T23:00:00+02:00Ottobre 28th, 2021|Categorie: Coronavirus NEJM|

As of June 6, 2021, approximately 175 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and 3.8 million deaths from coronavirus disease 2019 (Covid-19) have been reported worldwide. Programs providing unprecedented rapid c...

SARS-CoV-2 Neutralization with BNT162b2 Vaccine Dose 3 [language] = "en-us"

Di |2021-10-21T23:00:00+02:00Ottobre 21st, 2021|Categorie: Coronavirus NEJM|

To the Editor: We conducted a global, randomized, placebo-controlled, phase 1–2–3 pivotal trial in which two 30-μg doses of BNT162b2 (Pfizer–BioNTech) were administered 21 days apart (ClinicalTrials.gov number, NCT04368728). These doses of vaccine had ...

Peak Moments — When Kindergarten Is High Risk [language] = "en-us"

Di |2021-10-21T23:00:00+02:00Ottobre 21st, 2021|Categorie: Coronavirus NEJM|

Before my son left home on the first day of school, I took his photo — attempting, like generations of parents before me, to hit the "pause" button on life for a few seconds, capturing the start of a new chapter of childhood. The photo contained 5 year...

Audio Interview: A New Look at Covid-19 Vaccine Boosters [language] = "en-us"

Di |2021-10-21T23:00:00+02:00Ottobre 21st, 2021|Categorie: Coronavirus NEJM|

The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at t...

Effectiveness of the mRNA-1273 Vaccine during a SARS-CoV-2 Delta Outbreak in a Prison [language] = "en-us"

Di |2021-10-20T23:00:00+02:00Ottobre 20th, 2021|Categorie: Coronavirus NEJM|

To the Editor: The mRNA vaccines have been shown to be highly effective in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and associated illness, although recent reports suggest reduced effectiveness against infection...

Effectiveness of BNT162b2 Vaccine against Delta Variant in Adolescents [language] = "en-us"

Di |2021-10-20T23:00:00+02:00Ottobre 20th, 2021|Categorie: Coronavirus NEJM|

To the Editor: The B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as the dominant strain circulating in many regions worldwide. The BNT162b2 mRNA vaccine against coronavirus disease 2019 (Covid-19)...

Toxic Effects from Ivermectin Use Associated with Prevention and Treatment of Covid-19 [language] = "en-us"

Di |2021-10-20T23:00:00+02:00Ottobre 20th, 2021|Categorie: Coronavirus NEJM|

To the Editor: Ivermectin is approved by the Food and Drug Administration as an oral treatment for intestinal strongyloidiasis and onchocerciasis and as a topical treatment for pediculosis and rosacea. It is also used as a treatment for parasites in pe...

Covid-19 Vaccination during Pregnancy and First-Trimester Miscarriage [language] = "en-us"

Di |2021-10-20T23:00:00+02:00Ottobre 20th, 2021|Categorie: Coronavirus NEJM|

To the Editor: Pregnant women with coronavirus disease 2019 (Covid-19) are at increased risk for adverse outcomes, and Covid-19 vaccination is recommended during pregnancy. However, safety data on Covid-19 vaccination during pregnancy remain limited. W...