Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03411-xIn an ongoing adaptive-design trial exploring different combinations of neoadjuvant immunotherapies including the anti-PD-1 agent pembrolizumab, the anti...
Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03419-3Suraxavir marboxil, an antiviral drug designed to inhibit the polymerase acidic protein of influenza, alleviates symptoms in individuals with influenza f...
Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03428-2A phase 1/2 clinical trial of a new device-assisted therapy in Parkinson’s disease revealed that intracerebroventricular administration of anaerobic dopa...
Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03451-3In the final report of a phase 1 trial evaluating intracerebroventricular B7-H3-targeting CAR T cells in children and young adults with diffuse intrinsic...
Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03375-yA multicenter randomized controlled trial found that incorporating time-restricted eating, regardless of the timing of the eating window, into usual care...
Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03408-6In a large-scale prospective study run across 12 sites in Germany and involving 463,094 women and 119 radiologists, AI-supported screening increased brea...
Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03421-9In 1,088 pregnant individuals, assessment of abnormal serum angiogenic factors is demonstrated to be noninferior to the standard clinical approach based ...
Nature Medicine, Published online: 06 January 2025; doi:10.1038/s41591-024-03396-7Studies from wearables show that even small doses of physical activity provide health benefits; guidelines should be updated to reflect this.
Nature Medicine, Published online: 06 January 2025; doi:10.1038/s41591-024-03385-wA randomized controlled trial in the third trimester of pregnancy in Malawian women with anemia found a single dose of intravenous ferric carboxymaltose ...
Nature Medicine, Published online: 06 January 2025; doi:10.1038/s41591-024-03361-4In a phase 2 trial of adults with neurofibromatosis type 1 and inoperable/growing plexiform neurofibromas, treatment with the MEK inhibitor selumetinib r...
Nature Medicine, Published online: 06 January 2025; doi:10.1038/s41591-024-03401-zIn a single-arm phase 2b trial, glecirasib, an oral KRAS-G12C inhibitor, had an overall response rate of 47.9% in patients with locally advanced or metas...
Nature Medicine, Published online: 06 January 2025; doi:10.1038/s41591-024-03360-5In a multicenter, open-label, randomized phase 2 trial, neoadjuvant chemoradiation with PD-1 blockade elicited a pathological complete response rate supe...
Nature Medicine, Published online: 06 January 2025; doi:10.1038/s41591-024-03334-7In this phase 1 trial, patients with locally advanced or metastatic solid tumors were treated with the individualized mRNA neoantigen-specific immunother...
Nature Medicine, Published online: 06 January 2025; doi:10.1038/s41591-024-03398-5Using multiple datasets from real-world evidence and completed trials, a machine learning model using routine blood and clinical data is shown to be pred...
Nature Medicine, Published online: 06 January 2025; doi:10.1038/s41591-024-03364-1CANAIRI: the Collaboration for Translational Artificial Intelligence Trials in healthcare
Nature Medicine, Published online: 03 January 2025; doi:10.1038/s41591-024-03367-yPreparedness and priority research to tackle the mpox outbreak response