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Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

Di Neil A. Robertson|2022-07-04T22:00:00+02:00Luglio 4th, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 04 July 2022; doi:10.1038/s41591-022-01883-3An analysis of blood samples from longitudinal cohorts reveals insights on the dynamics of clonal hematopoiesis of indeterminate potential and proposes a mo...

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The promise of precision medicine in rheumatology

Di Joel M. Guthridge|2022-07-04T22:00:00+02:00Luglio 4th, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 04 July 2022; doi:10.1038/s41591-022-01880-6Precision medicine for rheumatic diseases is still in its infancy, but recent advances are enabling comprehensive profiling and mechanistic insights. This R...

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Comorbidities confound Alzheimer’s blood tests

Di Suzanne E. Schindler|2022-07-04T22:00:00+02:00Luglio 4th, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 04 July 2022; doi:10.1038/s41591-022-01875-3The concentrations of two key blood biomarkers for Alzheimer’s disease are affected by some medical conditions, which could potentially lead to misdiagnosis.

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Systematic pan-cancer analysis of mutation–treatment interactions using large real-world clinicogenomics data

Di Ruishan Liu|2022-06-30T22:00:00+02:00Giugno 30th, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 30 June 2022; doi:10.1038/s41591-022-01873-5A large-scale computational analysis of over 40,000 patients with cancer who have detailed mutation profiles, treatment sequences and outcomes derived from ...

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Diversity, equity and inclusion actions from the NCATS Clinical and Translational Science awarded programs

Di L. Ebony Boulware|2022-06-28T22:00:00+02:00Giugno 28th, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 28 June 2022; doi:10.1038/s41591-022-01863-7Diversity, equity and inclusion actions from the NCATS Clinical and Translational Science awarded programs

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How better pandemic and epidemic intelligence will prepare the world for future threats

Di Oliver W. Morgan|2022-06-28T22:00:00+02:00Giugno 28th, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 28 June 2022; doi:10.1038/s41591-022-01900-5A new approach to pandemic and epidemic intelligence is needed that includes modern approaches to surveillance and risk assessment, as well as improved trus...

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A new phase of the Cancer Moonshot to end cancer as we know it

Di Dinah S. Singer|2022-06-27T22:00:00+02:00Giugno 27th, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 27 June 2022; doi:10.1038/s41591-022-01881-5Improved screening, novel therapies and a focus on health equity can reduce cancer mortality by 50% in the next 25 years, but these must be underpinned by a...

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Rise in ambient temperature is associated with increased mortality in Latin America

Di Nature Medicine|2022-06-27T22:00:00+02:00Giugno 27th, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 27 June 2022; doi:10.1038/s41591-022-01893-1Climate change is projected to increase the frequency and intensity of extreme ambient temperatures, particularly in the Global South. By analyzing temperat...

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Emergence of SARS-CoV-2 Omicron lineages BA.4 and BA.5 in South Africa

Di Houriiyah Tegally|2022-06-27T22:00:00+02:00Giugno 27th, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 27 June 2022; doi:10.1038/s41591-022-01911-2Emergence of SARS-CoV-2 Omicron lineages BA.4 and BA.5 in South Africa

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City-level impact of extreme temperatures and mortality in Latin America

Di Josiah L. Kephart|2022-06-27T22:00:00+02:00Giugno 27th, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 27 June 2022; doi:10.1038/s41591-022-01872-6An ecological analysis of 326 cities in 9 countries across Latin America found that changes in ambient temperature have a substantial contribution to all-ca...

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<b>An anti-obesity drug from the diabetes toolbox</b>

Di Karen O’Leary|2022-06-27T22:00:00+02:00Giugno 27th, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 27 June 2022; doi:10.1038/d41591-022-00072-6In a phase 3 study, the diabetes drug tirzepatide brought about substantial and sustained weight reduction in adults with obesity.

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Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus

Di Joana Isidro|2022-06-24T20:00:00+02:00Giugno 24th, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 24 June 2022; doi:10.1038/s41591-022-01907-yPhylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus

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Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma

Di Andrew X. Zhu|2022-06-23T04:00:00+02:00Giugno 23rd, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 23 June 2022; doi:10.1038/s41591-022-01868-2Multiomics analysis of tumor samples from the phase 1b GO30140 and phase 3 IMbrave150 trials reveals baseline immune and genetic features that might identif...

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Cross-ancestry genome-wide polygenic score predicts chronic kidney disease

Di Nature Medicine|2022-06-23T04:00:00+02:00Giugno 23rd, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 23 June 2022; doi:10.1038/s41591-022-01871-7A new genome-wide polygenic risk score for chronic kidney disease (CKD) that combines APOL1 risk genotypes with polygenic effects was validated in 15 divers...

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Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer

Di Alanna J. Church|2022-06-23T00:00:00+02:00Giugno 23rd, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 23 June 2022; doi:10.1038/s41591-022-01856-6An interim report from the GAIN/iCat2 study shows that molecular profiling of pediatric solid malignancies clarifies diagnostic classifications and provides...

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Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer

Di Alanna J. Church|2022-06-23T15:00:00+02:00Giugno 23rd, 2022|Categorie: Coronavirus Nature|

Nature Medicine, Published online: 23 June 2022; doi:10.1038/s41591-022-01856-6An interim report from the GAIN/iCat2 study shows that molecular profiling of pediatric solid malignancies clarifies diagnostic classifications and provides...

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