Nature Medicine, Published online: 08 January 2025; doi:10.1038/s41591-024-03429-1In the second case in which a genetically modified pig heart was transplanted into a living person, the xenografted heart functioned well initially, but ...
Nature Medicine, Published online: 08 January 2025; doi:10.1038/s41591-024-03458-wThis analysis of the registry database DESCAR-T of more than 3,000 pediatric and adult patients with hematological malignancies who received CAR T cell t...
Nature Medicine, Published online: 08 January 2025; doi:10.1038/d41591-025-00001-3Satellite data assessing residential greenness across Italy indicate that thousands of deaths could be prevented by greening residential areas.
Nature Medicine, Published online: 08 January 2025; doi:10.1038/s41591-024-03455-zKRAS mutations are ubiquitous in pancreatic adenocarcinomas (PDACs) and are associated with poor outcomes. We leveraged a cohort of 2,336 PDAC tumors to ...
Nature Medicine, Published online: 08 January 2025; doi:10.1038/s41591-024-03425-5TRIPOD-LLM (transparent reporting of a multivariable model for individual prognosis or diagnosis–large language model) is a checklist of items considered...
Nature Medicine, Published online: 08 January 2025; doi:10.1038/s41591-024-03405-9The gut microbiota bacterium Ruminococcus gnavus is implicated in the development of cirrhotic liver encephalopathy through the production of neurotoxins.
Nature Medicine, Published online: 08 January 2025; doi:10.1038/s41591-024-03422-8A base-editing approach optimized to target the retina shows high editing rates in a mouse model of Stargardt disease, as well as in nonhuman primates an...
Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03407-7A multi-omics analysis of decidualization resistance, which is implicated in various gynecological and obstetric conditions, in patients with a history o...
Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03411-xIn an ongoing adaptive-design trial exploring different combinations of neoadjuvant immunotherapies including the anti-PD-1 agent pembrolizumab, the anti...
Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03419-3Suraxavir marboxil, an antiviral drug designed to inhibit the polymerase acidic protein of influenza, alleviates symptoms in individuals with influenza f...
Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03428-2A phase 1/2 clinical trial of a new device-assisted therapy in Parkinson’s disease revealed that intracerebroventricular administration of anaerobic dopa...
Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03451-3In the final report of a phase 1 trial evaluating intracerebroventricular B7-H3-targeting CAR T cells in children and young adults with diffuse intrinsic...
Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03375-yA multicenter randomized controlled trial found that incorporating time-restricted eating, regardless of the timing of the eating window, into usual care...
Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03408-6In a large-scale prospective study run across 12 sites in Germany and involving 463,094 women and 119 radiologists, AI-supported screening increased brea...
Nature Medicine, Published online: 07 January 2025; doi:10.1038/s41591-024-03421-9In 1,088 pregnant individuals, assessment of abnormal serum angiogenic factors is demonstrated to be noninferior to the standard clinical approach based ...
Nature Medicine, Published online: 06 January 2025; doi:10.1038/s41591-024-03360-5In a multicenter, open-label, randomized phase 2 trial, neoadjuvant chemoradiation with PD-1 blockade elicited a pathological complete response rate supe...