These phase 3 efficacy and safety data provide support for aztreonam–avibactam as a potential therapeutic option for complicated intra-abdominal infection or HAP–VAP caused by Gram-negative bacteria.
Metallo-β-lactamase enzymes, named because of the presence of one or two zinc ions at the catalytic site, are responsible for β-lactam antibiotic hydrolysis and are increasing in prevalence worldwide.1 Despite the increase in antibiotic development ove...
Human African trypanosomiasis is a neglected tropical disease that is usually fatal without treatment. WHO has revised its rhodesiense human African trypanosomiasis treatment guidelines on the basis of an independent systematic literature review and fo...
COVID-19 is no longer a global pandemic but remains a public health problem and new vaccine formulations are still being developed to target newly emerging variants.1 Current guidelines recommend annual vaccination for all people older than 50 years an...
Almost 18 months on from WHO declaring that COVID-19 no longer constitutes a global health emergency, governments internationally are working to evaluate their response to the pandemic and identify where improvements could be made. COVID-19: confrontin...
The COVID-19 pandemic raised unprecedented interest in communicable diseases and drew attention to (and sometimes criticism of) public health institutions globally. This broad interest in pandemic preparedness and public health authorities propelled Ba...
In COVID-19 and the right to health in Africa, editors Ebenezer Durojaye and Roopanand Mahadew bring together a series of essays exploring how COVID-19-related restrictions affected people's access to health in Africa. Authors of different chapters dis...
In mid-August, 2024, Médecins Sans Frontières was removed from a registry permitting it to operate in Russia, halting the organisation's tuberculosis programmes. Ed Holt reports.
We acknowledge the enormous efforts countries have made to achieve zero dog-mediated human rabies deaths, an initiative supported by United Against Rabies. An estimated 59 000 people die from rabies each year; most cases occur in Asia and Africa, prima...
Although there was a substantial decline in human rabies deaths over the past two decades, to eliminate dog-mediated human rabies by 2030, India needs to fast-track its actions by adopting a focused one-health approach. Integrating human and animal sur...
A new strain of Oropouche virus (OROV), a neglected zoonotic orthobunyavirus primarily transmitted to humans in peri-urban settings by Culicoides paraensis biting midges, is rapidly spreading, with autochthonous transmission detected in Bolivia, Brazil...
Tuberculous meningitis causes death or disability in approximately 50% of affected individuals and kills approximately 78 200 adults every year. Antimicrobial treatment is based on regimens used for pulmonary tuberculosis, which overlooks important dif...
Tuberculous meningitis causes death or disability in approximately 50% of affected individuals and kills approximately 78 200 adults every year. Antimicrobial treatment is based on regimens used for pulmonary tuberculosis, which overlooks important dif...
The constant emergence of SARS-CoV-2 variants and sublineages that evade control by neutralising antibodies induced upon infection, vaccination, or both requires the use of adapted vaccines. A vaccine adapted to the omicron XBB.1.5 variant became avail...
In vaccine-naive, SARS-CoV-2-positive adolescents, single-dose mRNA-1273.222 was effective against COVID-19 based on successful immunobridging to the two-dose mRNA-1273 primary series in young adults. The findings support a simplified single-dose vacci...
With ongoing genetic and antigenic evolution of the SARS-CoV-2 spike protein, the primary circulating variants are currently the omicron subvariants JN.1, KP.3, and LB.1.1.1 The effect of COVID-19 on adolescents has become increasingly evident as the p...