mRNA-based vaccines, as shown by licensed COVID-19 vaccines, are immunogenic and can offer protection from severe disease with high efficacy.1,2 With the recent approval of a novel mRNA-based vaccine against human respiratory syncytial virus (mRESVIA; ...
As for much of the world, COVID-19 has left an undeniable and long-lasting path of destruction throughout South Asia. Every country had its own response and consequently its own experience with the pandemic. Unfortunately, those worst affected are ofte...
How do we choose who to trust? During the unsettling COVID-19 pandemic, we all made decisions about who we could trust to keep us safe: a risk-weighing action that weighed up the people and systems we trusted to protect our health. In COVID-19 response...
Pins and needles, the latest play by Scottish writer Rob Drummond, takes on the incendiary topic of vaccine hesitancy. It seemingly draws on interviews conducted by Drummond, alongside excerpts from the writings of Edward Jenner (1749–1823), the pionee...
Oda Y, Kumagai Y, Kanai M, et al. 12-month persistence of immune responses to self-amplifying mRNA COVID-19 vaccines: ARCT-154 versus BNT162b2 vaccine. Lancet Infect Dis 2024; published online Oct 7. https://doi.org/10.1016/S1473-3099(24)00615-7—In thi...
Oda Y, Kumagai Y, Kanai M, et al. 12-month persistence of immune responses to self-amplifying mRNA COVID-19 vaccines: ARCT-154 versus BNT162b2 vaccine. Lancet Infect Dis 2024; published online Oct 7. https://doi.org/10.1016/S1473-3099(24)00615-7—In thi...
Brickley EB, Miranda-Filho DdB, Ximenes RAdA, on behalf of the MERG, ZBC-Consortium, and LIFE Zika Study members. Preparing for the rapid research response to the possible vertical transmission of Oropouche virus: lessons from a decade of congenital Zi...
Brickley EB, Miranda-Filho DdB, Ximenes RAdA, on behalf of the MERG, ZBC-Consortium, and LIFE Zika Study members. Preparing for the rapid research response to the possible vertical transmission of Oropouche virus: lessons from a decade of congenital Zi...
This cluster supports that avian C abortus strains can cause human infections and underlines that human-to-human transmission should be considered when tracing the source of such infections.
Stijn Raven and colleagues1 report emerging zoonotic infections caused by avian Chlamydia abortus strains resulting in severe community-acquired pneumonia. The authors describe a Dutch family cluster of community-acquired pneumonia with probable introd...
These findings provide a comprehensive assessment of Oropouche fever in Brazil and contribute to an improved understanding of the 2023–24 Oropouche virus re-emergence. Our exploratory in-vitro data suggest that the increased incidence might be related ...
We detected OROV IgM in six of 68 newborns with microcephaly of unknown cause. One infant who died had OROV RNA and antigen in several tissues, including the brain. The possibility of OROV vertical transmission and potential fetal harm must be investig...
Oropouche virus (OROV), an arbovirus of the Orthobunyavirus genus and Peribunyaviridae family, is a vector-transmitted virus in the Simbu serogroup. Simbuviruses have long had importance in veterinary medicine because of their ability to induce severe ...
Since early 2024, an unprecedented spread of the Oropouche virus has been observed in Brazil and beyond in Latin America. Severe clinical consequences have been described, including early reports of deaths in adults with acute neurological disease and ...
As this Editorial goes to press, The Lancet Infectious Diseases is publishing two papers with early results on the pathogenic potential of Oropouche virus (OROV), which is causing an unprecedented outbreak in the Americas. While such early data are key...
Nirsevimab, a long-acting monoclonal antibody targeting site Ø of the fusion (F) protein of the respiratory syncytial virus (RSV), was approved by the European Medicines Agency and the US Food and Drug Administration for the prevention of RSV infection...