Candida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality. Candidaemia and other forms of invasive candidiasis primarily affect patients who are immunocompromis...
Respiratory syncytial virus (RSV) is known to cause considerable respiratory infection-related morbidity and mortality worldwide.1,2 Estimates published in 2022 from the UK highlight the disproportionate clinical effect of RSV infection in older people...
As the Trump administration shuts down the USA's main foreign-aid agency, USAID, the effects on global health are already being felt. Talha Burki reports.
On Jan 20, 2025, President Donald Trump signed an executive order withdrawing the USA from WHO, with wide-ranging ramifications for global health. Cahal McQuillan reports.
There are no approved treatments for post-COVID-19 condition (also known as long COVID), a debilitating disease state following SARS-CoV-2 infection that is estimated to affect tens of millions of people. A growing body of evidence shows that SARS-CoV-...
After the rapid spread of the SARS-CoV-2 JN.1 (BA.2.86.1.1) variant,1 several descendant lineages of JN.1, including KP.2 (JN.1.11.1.2),2 KP.3 (JN.1.11.1.3),2 and KP.3.1.1 (JN.1.11.1.3.1.1),3 have emerged and rapidly spread globally. Subsequently, XEC ...
In The Lancet Infectious Diseases, Nazir Ismail and colleagues1 report the findings of a randomised controlled trial done in South Africa, showing that a combination of pre-test and post-test tuberculosis counselling and electronic conditional cash tra...
At this point in time, with US President Trump's administration attacking institutions such as the US CDC, NIH, USAID, WHO, and their people and functions, whether science should be political seems like a rhetorical question. To us, the only logical an...
The package of interventions consisting of pre-test and post-test tuberculosis counselling with conditional cash transfers significantly reduced the risk of unsuccessful tuberculosis patient outcomes, bringing one of the 90–90–90 targets within reach (...
Marginalised populations often have reduced access to infectious disease prevention interventions, and as a result of this and other socioeconomic factors, these populations are at a higher risk of disease. Here, we reviewed the literature of community...
Burkina Faso is among ten countries most affected by malaria. The global community still struggles to eliminate this debilitating disease that is a leading cause of mortality in children younger than 5 years.1 Public health efforts include treatment, c...
Repeated high-dose ivermectin MDA integrated with SMC distributions at the study site did not reduce malaria incidence among children relative to placebo MDA, despite evidence that, compared with the control group, mosquito survivorship in the first ye...
In response to the ongoing evolution of SARS-CoV-2, vaccine manufacturers have released updated COVID-19 vaccines annually since 2022. For much of 2024, the global spread was dominated by the JN.1 lineage of viruses,1 which are antigenically quite dist...
The rapid spread and emergence of immune-evasive SARS-CoV-2 variants has led to a 2024 update of the COVID-19 vaccine. These variants include BA.2.86-lineage variants comprising more than 30 mutations within the spike that are different from XBB-lineag...
COVID-19 represented a greater disease burden than influenza, with more hospital admissions and deaths, and more severe disease (primarily among non-vaccinated people, those with comorbidities, and male patients). These results highlight the continued ...
COVID-19 represented a greater disease burden than influenza, with more hospital admissions and deaths, and more severe disease (primarily among non-vaccinated people, those with comorbidities, and male patients). These results highlight the continued ...