[Correspondence] Predictable excess hepatotoxicity in the SimpliciTB trial – Authors’ reply

Di |2024-10-29T00:30:01+01:00Ottobre 29th, 2024|Categorie: Coronavirus Lancet|

William Burman and colleagues suggest that the hepatotoxicity of the bedaquiline, pretomanid, moxifloxacin, and pyrazinamide (BPaMZ) regimen observed in the SimpliciTB trial1 was predictable from the liver-related treatment emergent adverse events repo...

[Correspondence] Predictable excess hepatotoxicity in the SimpliciTB trial – Authors’ reply

Di |2024-10-29T00:30:01+01:00Ottobre 29th, 2024|Categorie: Coronavirus Lancet|

William Burman and colleagues suggest that the hepatotoxicity of the bedaquiline, pretomanid, moxifloxacin, and pyrazinamide (BPaMZ) regimen observed in the SimpliciTB trial1 was predictable from the liver-related treatment emergent adverse events repo...

[Articles] Serotype-specific epidemiological patterns of inapparent versus symptomatic primary dengue virus infections: a 17-year cohort study in Nicaragua

Di |2024-10-26T00:30:01+02:00Ottobre 26th, 2024|Categorie: Coronavirus Lancet|

Our study indicates that case surveillance skews the perceived epidemiological footprint of DENV. We reveal a more complex and intricate pattern of serotype distribution in inapparent infections. The substantial differences in infection outcomes by ser...

[Articles] Serotype-specific epidemiological patterns of inapparent versus symptomatic primary dengue virus infections: a 17-year cohort study in Nicaragua

Di |2024-10-26T00:30:01+02:00Ottobre 26th, 2024|Categorie: Coronavirus Lancet|

Our study indicates that case surveillance skews the perceived epidemiological footprint of DENV. We reveal a more complex and intricate pattern of serotype distribution in inapparent infections. The substantial differences in infection outcomes by ser...

[Articles] The effect of Plasmodium falciparum exposure and maternal anti-circumsporozoite protein antibodies on responses to RTS,S/AS01E vaccination in infants and children: an ancillary observational immunological study to a phase 3, randomised clinical trial

Di |2024-10-24T00:30:01+02:00Ottobre 24th, 2024|Categorie: Coronavirus Lancet|

Interference between passive immunity and vaccine response is clinically significant and might affect the implementation of next-generation CSP-based vaccines for young infants and mothers as well as passive immunisation with human monoclonal antibodies.

[Articles] Immunogenicity of a booster dose of a bivalent (Asp614Gly and omicron BA.4/5 variant) self-amplifying mRNA SARS-CoV-2 booster vaccine versus the BNT162b2 omicron BA.4/5 mRNA vaccine: a randomised phase 3 trial

Di |2024-10-24T00:30:01+02:00Ottobre 24th, 2024|Categorie: Coronavirus Lancet|

Boosting mRNA-immunised adults with ARCT-2301 induced superior immunogenicity compared with Comirnaty BA.4-5 against both Wuhan-Hu-1 and omicron BA.4/5 variant COVID-19, and elicited a higher response against omicron XBB.1.5. Both vaccines had similar ...

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