There are 100 known serotypes of Streptococcus pneumoniae,1 and pneumococcal conjugate vaccines (PCVs) are highly effective at protecting against disease from serotypes included in the vaccine. PCVs contain selected pneumococcal polysaccharides that ar...
“History has the power to shape not only what we remember, but what we forget.” In the final paragraph of the introduction to In Her Hands, Women's Fight Against AIDS in the United States, historian Emma Day perfectly sums up the message behind her boo...
“History has the power to shape not only what we remember, but what we forget.” In the final paragraph of the introduction to In Her Hands, Women's Fight Against AIDS in the United States, historian Emma Day perfectly sums up the message behind her boo...
Webster E, Palanco Lopez P, Kirchhelle C. Shifting targets: typhoid's transformation from an environmental to a vaccine-preventable disease, 1940–2019. Lancet Infect Dis 2023; published online Nov 20. https://doi.org/10.1016/S1473-3099(23)00500-5—In th...
Webster E, Palanco Lopez P, Kirchhelle C. Shifting targets: typhoid's transformation from an environmental to a vaccine-preventable disease, 1940–2019. Lancet Infect Dis 2023; published online Nov 20. https://doi.org/10.1016/S1473-3099(23)00500-5—In th...
To accelerate the clinical development and evaluation of new or improved health interventions for the accurate diagnosis, treatment, and prevention of poverty-related infectious diseases in Africa, in 2003 the EU launched the European & Developing Coun...
To accelerate the clinical development and evaluation of new or improved health interventions for the accurate diagnosis, treatment, and prevention of poverty-related infectious diseases in Africa, in 2003 the EU launched the European & Developing Coun...
During the unprecedented 2013–16 Ebola Zaire epidemic, several academic researchers developed tools to mitigate Ebola virus disease. These tools primarily included the production of competent vesicular stomatitis virus-based vaccine expressing a surfac...
Almost a quarter of survivors were seronegative on discharge from the Ebola treatment centre and antibody concentrations decreased rapidly over time. These results indicate that monoclonal antibodies might negatively affect the production of anti-Ebola...
Fracture-related infection is a major complication related to musculoskeletal injuries that not only has important clinical consequences, but also a substantial socioeconomic impact. Although fracture-related infection is one of the oldest disease enti...
The 2023 Marburg virus disease outbreaks in Equatorial Guinea and Tanzania highlighted the importance of better understanding this lethal pathogen. We did a systematic review (PROSPERO CRD42023393345) of peer-reviewed articles reporting historical outb...
This Comment reflects our experience of deploying the Oxford-Royal College of General Practitioner's Research and Surveillance Centre (RSC), England's primary care sentinel network, in response to the COVID-19 pandemic.
The ChAdOx1 85A–MVA85A regimen was safe and induced stronger Ag85A-specific responses than BCG revaccination. Our findings support further development of booster tuberculosis vaccines.
With continued wild poliovirus transmission in Afghanistan and Pakistan and circulating vaccine-derived poliovirus in certain countries, there exists an ongoing risk of importation of polioviruses into other countries, including those that have been po...
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Despite the remarkable efficacy of the BCG vaccine in preventing tuberculosis in infants, its effectiveness is scarce in high-burden areas and in adults.1 Therefore, the search...
Invasive fungal infections mainly affect hospitalised patients and are often unrecognised or even underestimated. Mortality among patients with invasive fungal infections remains high (25–60%) despite existing treatments due to patients' background but...