Influenza viruses are important human pathogens that cause seasonal outbreaks and have the potential to cause global pandemics. The ongoing evolution of influenza viruses poses a public health challenge, as antigenic drift (ie, the accumulation of muta...
Overall, IPD incidence in England was lower in 2022–23, 2 years after removal of pandemic restrictions, than in 2019–20. Breakthrough and vaccine failure rates were not significantly different between children who received the 1 + 1 compared with the 2...
Chimeric antigen receptor (CAR) T-cell therapy leads to durable remissions in relapsed B-cell cancers, but treatment-associated immunocompromise leads to a substantial morbidity and mortality risk from atypical infection. Mucormycosis is an aggressive ...
Pneumococcal conjugate vaccine (PCV) is one of the most expensive vaccines in the paediatric vaccination schedule. To reduce cost and the number of injections, there has been major research investments to identify whether a two-dose infant PCV schedule...
Of the many effective vaccines developed to combat the COVID-19 pandemic, the most notable were novel mRNA vaccines. Despite their high efficacy against the original Wuhan-Hu-1 strain and early SARS-CoV-2 variants, mRNA vaccines elicit a relatively sho...
To identify people with low-risk Staphylococcus aureus bacteraemia, the SABATO investigators screened 5063 people, finding 213 (4·2%) individuals who met their eligibility criteria.1 This low proportion of eligible patients led the authors to question ...
There are an estimated 140 000 cases of zoonotic tuberculosis each year that result in approximately 11 400 deaths.1 However, these estimates are subject to certain caveats, one of which is the definition of zoonotic tuberculosis. WHO, World Organisati...
The ongoing Israel–Hamas war in Gaza has led to a severe health crisis, notably affecting children younger than 5 years with a substantial increase in infectious diseases. The situation is dire, with a UN report indicating around 179 000 acute respirat...
Bosh-Nicolau P, Fernandez ML, Sulleiro E, et al. Efficacy of three benznidazole dosing strategies for adults living with chronic Chagas disease (MULTIBENZ): an international, randomised, double-blind, phase 2b trial. Lancet Infect Dis 2024; published o...
Malembaka EB, Bugeme PM, Hutchins C, et al. Effectiveness of one dose of killed oral cholera vaccine in an endemic community in the Democratic Republic of the Congo: a matched case-control study. Lancet Infect Dis 2024; published online Jan 18. https:/...
Malembaka EB, Bugeme PM, Hutchins C, et al. Effectiveness of one dose of killed oral cholera vaccine in an endemic community in the Democratic Republic of the Congo: a matched case-control study. Lancet Infect Dis 2024; published online Jan 18. https:/...
Since its discovery in 1955, the incidence and geographical spread of reported Oropouche virus (OROV) infections have increased. Oropouche fever has been suggested to be one of the most important vector-borne diseases in Latin America. However, both li...
Masking was one of the most visible and prominent features of COVID-19. People who had never seen a facemask before started wearing them daily to curb the spread of the virus. In the recently published book, Social and ethical issues of global pandemic...
In The public health approach: population thinking from the Black Death to COVID-19, distinguished physician and epidemiologist Alfredo Morabia, advocates eloquently for what he terms a public health approach. Citing the 200 million Americans who were ...
We found no significant difference in estimated effectiveness of the two oral vaccines, supporting the recommendation that the more genetically stable nOPV2 should be preferred in cVDPV2 outbreak response. Our findings highlight the role of IPV and the...
A single dose of Euvichol-Plus provided substantial protection against medically attended cholera for at least 36 months after vaccination in this cholera-endemic setting. Although the evidence provides support for similar levels of protection in young...