Malaria remains one of the most important infectious diseases in the world, with the greatest burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The treatment and control of malaria is challenged by resistance to most availab...
Overall, the vaccine regimen and booster dose were well tolerated. A similar and robust humoral immune response was observed for participants boosted 1 year and 2 years after the first dose, supporting the use of the regimen and flexibility of booster ...
Dengue, a global health problem, is caused by dengue virus (DENV), of which there are four serotypes (DENV1–4).1 A person infected via a mosquito bite will have no symptoms or show clinical manifestations ranging from dengue fever, a mild flu-like synd...
The identification of Mycobacterium tuberculosis as a causal agent of tuberculosis revolutionised the understanding of human diseases by showing that some have an infectious origin. How M tuberculosis spreads remained speculative until pioneering work—...
The risk of developing virologically confirmed dengue after a single dose of CYD-TDV varied by baseline DENV serostatus. Since the study assessed the effect of only a single dose, the findings cannot inform decisions on vaccination by public health off...
On March 24, every year, the world is reminded of the public health tragedy of tuberculosis and urged to take action to enhance efforts to end this disease globally. Although progress has been made, by 2022, over 10 million people had developed the dis...
Drug-resistant tuberculosis (DR-TB) threatens to derail tuberculosis control efforts, particularly in Africa where the disease remains out of control. The dogma that DR-TB epidemics are fueled by unchecked rates of acquired resistance in inadequately t...
The SARS-CoV-2 variant JN.1 swiftly became the global dominant strain1,2 due to a spike protein Leu455Ser substitution, boosting transmissibility and immune-escape capabilities, surpassing its predecessor BA.2.86 and other variants.1,3,4 These alterati...
The meningococcal group B vaccine, 4CMenB, is a broad-spectrum, recombinant protein vaccine that is licensed for protection against meningococcal group B disease in children and adults. Over the past decade, several observational studies supported by l...
Despite accelerated progress in reducing the global burden of tuberculosis in the past decade, the world did not attain the first interim milestones of the WHO End TB Strategy in 2020. The pace of decline has been unequal with respect to age, with olde...
mRNA-1273.214 was immunogenic against BA.1 and D614G in children aged 6 months to 5 years, with a comparable safety profile to mRNA-1273, when given as a two-dose primary series or a booster dose. These results are aligned with the US Centers for Disea...
With the prolonged circulation of SARS-CoV-2 and the widespread administration of COVID-19 vaccines, the immunity against SARS-CoV-2 in adults is predominantly due to previous variant exposures, vaccination, or both.1,2 However, as immunity due to vacc...
In February, the Alaska Division of Public Health reported the first death from a recently discovered virus belonging to the same genus as smallpox and mpox. Sharmila Devi reports.
We, as co-chairs of the Panel of Experts of the Global Burden of Disease Independent Advisory Committee (GBD IAC)'s Deep Dive into the Institute for Health Metrics and Evaluation (IHME)'s tuberculosis estimates, welcome publication of GBD 2021 Tubercul...
Soil-transmitted helminth infections, comprising Ascaris lumbricoides, Trichuris trichiura, and the two hookworm species Ancylostoma duodenale and Necator americanus, are responsible for an immense burden on public health.1 For decades, large-scale dis...
Soil-transmitted helminth infections, comprising Ascaris lumbricoides, Trichuris trichiura, and the two hookworm species Ancylostoma duodenale and Necator americanus, are responsible for an immense burden on public health.1 For decades, large-scale dis...