Although malaria has placed a burden on humanity for centuries, affecting millions of people, particularly in Africa, numerous strategies and interventions have been implemented with varying degrees of success.1 The recent introduction of the R21/Matri...
Chikungunya virus is a mosquito-transmitted alphavirus first detected in Tanzania in the 1950s. However, it was only after a large outbreak in Réunion island that the risk of severe disease in humans started becoming clear.1 Outbreaks of chikungunya vi...
Chikungunya virus is a mosquito-transmitted alphavirus first detected in Tanzania in the 1950s. However, it was only after a large outbreak in Réunion island that the risk of severe disease in humans started becoming clear.1 Outbreaks of chikungunya vi...
In their Comment, Robert L Gottlieb and Roger Paredes stated “deuteration is merely an artistic flourish, inconsequential to antiviral pharmacology. The drug would have the same effect regardless of deuteration.”1 This perspective, we argue, overlooks ...
In the 40 years since the Ebola virus was first identified, there has been an increase in the size and frequency of epidemics of Ebola virus and other high-consequence pathogens. Although such health emergencies are often measured by numbers of infecti...
To our knowledge, this is the first observational study describing the protective effect of rVSVΔG-ZEBOV-GP vaccination against death among patients with confirmed Ebola virus disease admitted to an Ebola health facility. Vaccination was protective aga...
SARS-CoV-2 causes persistent infections in a subset of individuals, which is a major clinical and public health problem that should be prioritised for further investigation for several reasons. First, persistent SARS-CoV-2 infection often goes unrecogn...
A fractional dose of the 17DD yellow fever vaccine induced an immunologic response with detectable titres at 5 years among the majority of participants in the Democratic Republic of the Congo. These findings support the use of fractional-dose vaccinati...
In 2016, major vaccine supply shortages during large yellow fever outbreaks in Africa prompted WHO to issue interim recommendations to use fractional dosing of yellow fever vaccines as a dose sparing strategy.1 Following this, one fifth of the standard...
Onradivir showed a safety profile comparable to placebo, as well as higher efficacy than placebo in ameliorating influenza symptoms and lowering the viral load in adult patients with uncomplicated influenza infection, especially the onradivir 600 mg on...
Influenza viruses are important human pathogens that cause seasonal outbreaks and have the potential to cause global pandemics. The ongoing evolution of influenza viruses poses a public health challenge, as antigenic drift (ie, the accumulation of muta...
Overall, IPD incidence in England was lower in 2022–23, 2 years after removal of pandemic restrictions, than in 2019–20. Breakthrough and vaccine failure rates were not significantly different between children who received the 1 + 1 compared with the 2...
Chimeric antigen receptor (CAR) T-cell therapy leads to durable remissions in relapsed B-cell cancers, but treatment-associated immunocompromise leads to a substantial morbidity and mortality risk from atypical infection. Mucormycosis is an aggressive ...
Pneumococcal conjugate vaccine (PCV) is one of the most expensive vaccines in the paediatric vaccination schedule. To reduce cost and the number of injections, there has been major research investments to identify whether a two-dose infant PCV schedule...
Of the many effective vaccines developed to combat the COVID-19 pandemic, the most notable were novel mRNA vaccines. Despite their high efficacy against the original Wuhan-Hu-1 strain and early SARS-CoV-2 variants, mRNA vaccines elicit a relatively sho...
To identify people with low-risk Staphylococcus aureus bacteraemia, the SABATO investigators screened 5063 people, finding 213 (4·2%) individuals who met their eligibility criteria.1 This low proportion of eligible patients led the authors to question ...