The SARS-CoV-2 JN.1 variant (BA.2.86.1.1), arising from BA.2.86.1 with spike-protein substitution Leu455Ser, had outcompeted the previously predominant XBB lineages by the beginning of 2024.1 Subsequently, JN.1 subvariants, including KP.2 (JN.1.11.1.2)...
June, 2024, marked 40 years since Barry Marshall and Robin Warren published their seminal work implicating Helicobacter pylori in gastritis and peptic ulcers. Udani Samarasekera reports.
Chang CC, Harrison TS, Bicanic TA, et al. Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM. Lancet Infect Dis 2024; published online Feb 9. https://doi.org/10.1016/S147...
Emerging severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron subvariants are considered antigenically distinct, defined by escape from neutralising antibodies. To assess the antigenic distance between variants and predict immunity gaps...
In the 2024 study by Ann R Falsy and colleagues, the Ad26.RSV.preF–RSV preF protein vaccine offered strong protection against respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD) in healthy adults aged 65 years or older (84·1%) and ...
In her book Eclipsed: overcoming disease, despondency and doldrum, author Akshata Acharya, a survivor of multidrug-resistant tuberculosis (MDR-TB), speaks about her journey of fighting tuberculosis (TB).
At present, there is an unprecedented upsurge of cases of severe intrauterine infection with parvovirus B19 in northwestern Europe. Parvovirus B19 is well known as the causative agent of erythema infectiosum (also known as fifth disease), a common and ...
Obert Tanner created the Tanner Lectures in 1975 to contribute to “the moral and intellectual life” of humankind. Approaching its 50th anniversary, the program has provided a discussion space for scholars, writers, artists, and political leaders alike....
Underbelly: childhood diarrhoea and the hidden local realities of global health by Rachel Hall-Clifford is an ethnographic study examining childhood diarrhoea and its remedies in Guatemala's Mayan communities. As a Mayan child, during Guatemala's armed...
Dattwyler RJ, Arnaboldi PM. Vaccination hesistancy in Lyme borreliosis. Lancet Infect Dis 2024; published online May 31. https://doi.org/10.1016/S1473-3099(24)00221-4—In this Comment, the declaration of interests has been updated. This correction has b...
The RH5.1/Matrix-M vaccine candidate shows an acceptable safety and reactogenicity profile in both adults and 5–17-month-old children residing in a malaria-endemic area, with all children in the delayed third dose regimen reaching a level of GIA previo...
The high treatment success and good safety results indicate considerable potential for the use of mSTRs in programmatic conditions, especially for individuals not eligible for the current WHO-recommended 6-month regimen and in settings with a need for ...
Yearly, about 410 000 patients worldwide develop rifampicin-resistant tuberculosis, resistant to the most powerful first-line tuberculosis drug. In 2012, treatment for rifampicin-resistant tuberculosis constituted mainly regimens of 18 months or longer...
In The Lancet Infectious Diseases, Sarah E Silk and colleagues1 present advances in the clinical development of the leading blood-stage malaria vaccine candidate. A collaboration between UK and Tanzanian investigators, the authors report the first-in-h...
Avian influenza virus continues to pose zoonotic, epizootic, and pandemic threats worldwide, as exemplified by the 2020–23 epizootics of re-emerging H5 genotype avian influenza viruses among birds and mammals and the fatal jump to humans of emerging A(...
Cholera remains a global threat to health security, particularly in sub-Saharan Africa where outbreaks have become frequent, with increased magnitude and fatalities.1,2 While the world is preparing for the next pandemic, we explored clinical outcomes a...