Czech Republic is experiencing the largest outbreak of pertussis in more than 60 years, with suboptimal vaccine coverage and waning immunity partly to blame. Ed Holt reports.

Recognition of misinformation as a public health threat and interest in infodemics, defined as an inundation of information accompanying an epidemic or acute health event, have increased worldwide. However, scientists have no consensus on how to best d...

Recognition of misinformation as a public health threat and interest in infodemics, defined as an inundation of information accompanying an epidemic or acute health event, have increased worldwide. However, scientists have no consensus on how to best d...

Our detailed breakdown of DALYs associated with a comprehensive list of pathogens on a global, regional, and country level has revealed the magnitude of the problem and helps to indicate where research funding mismatch might exist. Given the disproport...

Our detailed breakdown of DALYs associated with a comprehensive list of pathogens on a global, regional, and country level has revealed the magnitude of the problem and helps to indicate where research funding mismatch might exist. Given the disproport...

In 2019, 2540 million (95% uncertainty interval [UI] 2290–2810) disability-adjusted life years (DALYs) were attributed to non-communicable and communicable diseases and injuries globally.1 In The Lancet Infectious Diseases, the IHME Pathogen Core Group...

In 2019, 2540 million (95% uncertainty interval [UI] 2290–2810) disability-adjusted life years (DALYs) were attributed to non-communicable and communicable diseases and injuries globally.1 In The Lancet Infectious Diseases, the IHME Pathogen Core Group...

Substantial progress has been made in reducing LRI mortality, but the burden remains high, especially in low-income and middle-income countries. During the COVID-19 pandemic, with its associated non-pharmaceutical interventions, global incident LRI cas...

Lower respiratory infections (LRIs) are the leading infectious cause of morbidity and mortality globally.1 The 2019 iteration of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) highlighted the major progress in reducing the incide...

This first-in-human aerosol BCG controlled human infection model was sufficiently well tolerated. Further work will evaluate the utility of this model in assessing vaccine efficacy and identifying potential correlates of protection.

Tuberculosis remains a formidable global health challenge, causing substantial morbidity and mortality due to the limited protection in the lungs provided by the current BCG vaccine.1 The urgent need for an effective tuberculosis vaccine has prompted i...

CTH522, adjuvanted with CAF01 or CAF09b, is safe and immunogenic, with 85 μg CTH522-CAF01 inducing robust serum IgG binding titres. Intradermal vaccination conferred systemic IgG neutralisation breadth, and topical ocular administration increased ocula...

A vaccine against chlamydia is widely agreed to be an essential public health control measure for both sexually transmitted and ocular infections.1 There have been many decades and much investment in research towards a chlamydial vaccine, and it has be...

Varicella, also known as chickenpox, is an infectious disease with a characteristic skin rash caused by the Varicella zoster virus. After the initial infection, varicella zoster virus can remain dormant and potentially reactivate in later life as herpe...

The three dose groups of the candidate v7D vaccine exhibit similar humoral immunogenicity to the vOka vaccine and are well tolerated. These findings encourage further investigations on two-dose vaccination schedules, efficacy, and the potential safety ...

Despite the non-specific and mild presentation of L monocytogenes-associated spontaneous bacterial peritonitis, the outcome is poor and similar to that of neurolisteriosis, and so identification of L monocytogenes in ascitic fluid samples requires urge...