Respiratory syncytial virus (RSV) remains a major cause of life-threatening respiratory illness in older adults. Estimates suggest that more than 30 000 adults older than 60 years die from RSV every year in high-income countries.1 However, after almost...
Doxycycline PEP strongly reduced the incidence of chlamydia and syphilis in MSM, but we did not show efficacy of the 4CmenB vaccine for gonorrhoea. Doxycycline PEP should be assessed in other populations, such as heterosexual men and women, and its eff...
Globally, there are more than 1 million sexually transmitted infections (STIs) acquired every day,1 with men who have sex with men (MSM) and transgender women being disproportionately impacted.2 In the past 5 years, studies have examined the potential ...
Ares-Gómez S, Mallah N, Santiago-Pérez M-I, et al. Effectiveness and impact of universal prophylaxis with nirsevimab in infants against hospitalisation for respiratory syncytial virus in Galicia, Spain: initial results of a population-based longitudina...
Targeted NGS is highly sensitive and specific for detecting drug resistance across panels of tuberculosis drugs and can be performed directly on clinical samples. There is a paucity of data on performance for some currently recommended drugs. The barri...
Drug-resistant tuberculosis causes 30% of all deaths due to antimicrobial resistance.1 One in three patients do not survive treatment for rifampicin-resistant tuberculosis and most have to pay catastrophic costs for their treatment.2 In 2015, it was pr...
Loss is pervasive, and COVID-19 accentuated its inescapable nature. Loss of life, health, economic security, and social well-being affected us all. Loss and trauma in the COVID-19 era is a collection of essays originally published in the Journal of Los...
Cullen Reese's The measle outbreak in Manatee Bay: complete story of the breakout, effective prevention, lessons, challenges, and strategies for healthier communities focuses on a measles outbreak that took place in early 2024 at Manatee Bay Elementary...
Military medicine and the hidden costs of war is the third publication by award winning Professor of Political Science, Tanisha M Fazal. Forming part of Oxford University Press's Bridging The Gap' series, this book is a comprehensive study of how the U...
Sometime around August 2015, health care providers in northeastern Brazil noticed an unusual number of babies born with severe microcephaly. A gynaecologist in a hospital in Campino Grande in Paraíba, for example, who would typically expect to see one ...
The JN.1 variant (BA.2.86.1.1), arising from BA.2.86.1 with the S:L455S substitution, showed increased fitness and outcompeted the previous dominant XBB lineage by the beginning of 2024.1 JN.1 subsequently diversified, leading to the emergence of desce...
Elimination of leprosy as a public health problem (prevalence of fewer than one leprosy case per 10 000 people) was attained in the majority of countries by 2010. Still, this neglected tropical disease is found in over 120 countries, with more than 200...
For DS-TB, BPaMZ successfully met the primary efficacy endpoint of sputum culture conversion. The regimen did not meet the key secondary efficacy endpoint due to adverse events resulting in treatment withdrawal. Our study demonstrated the potential for...
In 1948, the pioneering study that introduced streptomycin as the first treatment for tuberculosis (TB) was published, but the rapid onset of drug-resistant strains restricted the long-term benefit of streptomycin monotherapy.1 This led to the explorat...
Compared with other SARS-CoV-2 variants, BA.2.86 and the JN.1 sublineage were less sensitive to vaccine-induced immune protection from the XBB.1.5 updated COVID-19 vaccine; however, we found no evidence that infection with BA.2.86 or JN.1 resulted in i...
The constant transformation of SARS-CoV-2 poses considerable challenges for COVID-19 vaccine programmes. Since it was first detected in August, 2023, the SARS-CoV-2 omicron subvariant BA.2.86, and in particular the sublineage JN.1, have rapidly spread ...