Routine surveillance programmes mainly focus on known diseases and clinical syndromes of local importance. However, to be prepared for pathogen X, early detection of unusual illnesses or new pathogens is crucial. With the risk of global spread, timely,...
Chen SC-A, Perfect J, Colombo AL, et al. Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM. Lancet Infect Dis 2021; 21: e375–86—In figure 5 of this Review, the dose f...
Chen SC-A, Perfect J, Colombo AL, et al. Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM. Lancet Infect Dis 2021; 21: e375–86—In figure 5 of this Review, the dose f...
The diagnosis of paediatric tuberculosis remains a challenge due to the non-specificity of symptoms and the paucibacillary nature of tuberculosis in children. However, in the development of new tuberculosis diagnostics, the unique needs of children and...
In 2016, WHO designated Lassa fever a priority disease for epidemic preparedness as part of the WHO Blueprint for Action to Prevent Epidemics. One aspect of preparedness is to promote development of effective medical countermeasures (ie, diagnostics, t...
V116 was non-inferior to PCV20 for the ten serotypes common to both vaccines and superior to PCV20 for all serotypes unique to V116, except for 15C. Immune responses successfully immunobridged between younger and older adults for all serotypes in V116....
Nipah virus causes highly lethal disease, with case-fatality rates ranging from 40% to 100% in recognised outbreaks. No treatments or licensed vaccines are currently available for the prevention and control of Nipah virus infection. In 2019, WHO publis...
Pneumonia causes a considerable burden of disease, especially in adults older than 65 years who have higher rates of related hospital admission and deaths.1 Infections with pneumococcal bacteria are a substantial contributor to the global pneumonia bur...
Doxycycline as a post-exposure prophylaxis (doxy-PEP) reduces rates of bacterial sexually transmitted infections (STIs).1 However, doxy-PEP might select for tetracycline resistance in Neisseria gonorrhoeae and coresistance to other antibiotics, includi...
The SARS-CoV-2 JN.1 variant (BA.2.86.1.1), arising from BA.2.86.1 with spike-protein substitution Leu455Ser, had outcompeted the previously predominant XBB lineages by the beginning of 2024.1 Subsequently, JN.1 subvariants, including KP.2 (JN.1.11.1.2)...
June, 2024, marked 40 years since Barry Marshall and Robin Warren published their seminal work implicating Helicobacter pylori in gastritis and peptic ulcers. Udani Samarasekera reports.
Chang CC, Harrison TS, Bicanic TA, et al. Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM. Lancet Infect Dis 2024; published online Feb 9. https://doi.org/10.1016/S147...
In the 2024 study by Ann R Falsy and colleagues, the Ad26.RSV.preF–RSV preF protein vaccine offered strong protection against respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD) in healthy adults aged 65 years or older (84·1%) and ...
Emerging severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron subvariants are considered antigenically distinct, defined by escape from neutralising antibodies. To assess the antigenic distance between variants and predict immunity gaps...
In her book Eclipsed: overcoming disease, despondency and doldrum, author Akshata Acharya, a survivor of multidrug-resistant tuberculosis (MDR-TB), speaks about her journey of fighting tuberculosis (TB).
At present, there is an unprecedented upsurge of cases of severe intrauterine infection with parvovirus B19 in northwestern Europe. Parvovirus B19 is well known as the causative agent of erythema infectiosum (also known as fifth disease), a common and ...