[Newsdesk] Gilead under fire over HIV drug licensing
New licensing agreements for production of a generic version of HIV drug lenacapavir have been heavily criticised by activists who say they are too restrictive. Ed Holt reports.
[Correspondence] Impact of JN.1 booster vaccination on neutralisation of SARS-CoV-2 variants KP.3.1.1 and XEC
The SARS-CoV-2 KP.3.1.1 lineage is currently the dominating lineage on several continents. In parallel, the XEC lineage, a recombinant of KS.1.1 and KP.3.3,1 is rapidly gaining prevalence in Europe and North America, and is on track to become the next ...
[Personal View] Research and product development for Crimean–Congo haemorrhagic fever: priorities for 2024–30
Crimean–Congo haemorrhagic fever (CCHF) is a widely distributed and potentially fatal tick-borne viral disease with no licensed specific treatments or vaccines. In 2019, WHO published an advanced draft of a research and development roadmap for CCHF tha...
[Articles] A series of patients infected with the emerging tick-borne Yezo virus in China: an active surveillance and genomic analysis
Awareness of YEZV infection is important and clinicians should consider the virus when diagnosing patients with suitable symptoms.
[Comment] Endemic area of emerging tick-borne Yezo virus infections discovered in China
Yezo virus is a causative agent of tick-borne febrile illness first recognized in Hokkaido, the northernmost island of Japan, in 2019 (reported in 2021). Yezo virus is a member of the genus Orthonairovirus and family Nairoviridae, and is phylogenetical...
[Corrections] Correction to Lancet Infect Dis 2024; published online October 7. https://doi.org/10.1016/S1473-3099(24)00561-9
Heil EL, McCreary EK. REVISITing treatment of metallo-β-lactamases. Lancet Infect Dis 2024; published online Oct 7. https://doi.org/10.1016/S1473-3099(24)00561-9—In this Comment, two corrections have been made. The correct treatment difference for clin...
[Comment] A step closer to elimination of meningococcal disease
Invasive meningococcal disease continues to be a life-threatening infectious disease with rapid clinical progression and a case-fatality rate of up to 20% in young adults.1 In 2019, an estimated 2·51 million cases of meningitis occurred globally, with ...
[Articles] Safety and immunogenicity of a pentavalent meningococcal conjugate vaccine versus a quadrivalent meningococcal conjugate vaccine in adults in India: an observer-blind, randomised, active-controlled, phase 2/3 study
NmCV-5 was non-inferior to MenACWY-D in terms of seroresponse and GMTs, was safe, and demonstrated lot-to-lot consistency. NmCV-5 is prequalified by WHO and was rolled out in the African meningitis belt in April, 2024.
[Correspondence] Virological characteristics of the SARS-CoV-2 XEC variant
The SARS-CoV-2 JN.1 (BA.2.86.1.1) variant, arising from BA.2.86.1 with spike protein (S) substitution S:L455S, outcompeted the previously predominant XBB lineages by the beginning of 2024.1 Subsequently, JN.1 subvariants including KP.2 (JN.1.11.1.2) an...
[Grand Round] A case of disseminated autochthonous Cladophialophora bantiana infection in a renal transplant recipient in the UK
Disease associated with Cladophialophora bantiana infection is uncommon but can be characterised by severe and life-threatening CNS involvement. Diagnosis is challenging due to both the infection's rarity and non-specific clinical presentation, which c...
[Grand Round] A case of disseminated autochthonous Cladophialophora bantiana infection in a renal transplant recipient in the UK
Disease associated with Cladophialophora bantiana infection is uncommon but can be characterised by severe and life-threatening CNS involvement. Diagnosis is challenging due to both the infection's rarity and non-specific clinical presentation, which c...
[Corrections] Correction to Lancet Infect Dis 2024; published online Oct 10. https://doi.org/10.1016/S1473-3099(24)00507-3
Babiker A, Warner S, Li X, et al. Adjunctive linezolid versus clindamycin for toxin inhibition in β-lactam-treated patients with invasive group A streptococcal infections in 195 US hospitals from 2016 to 2021: a retrospective cohort study with target t...
[Corrections] Correction to Lancet Infect Dis 2024; published online Oct 10. https://doi.org/10.1016/S1473-3099(24)00507-3
Babiker A, Warner S, Li X, et al. Adjunctive linezolid versus clindamycin for toxin inhibition in β-lactam-treated patients with invasive group A streptococcal infections in 195 US hospitals from 2016 to 2021: a retrospective cohort study with target t...
[Articles] Evaluating culture-free targeted next-generation sequencing for diagnosing drug-resistant tuberculosis: a multicentre clinical study of two end-to-end commercial workflows
This multicentre evaluation demonstrates that culture-free tNGS can provide accurate sequencing results for detection and characterisation of drug resistance from Mycobacterium tuberculosis clinical sediment samples for timely, comprehensive profiling ...
[Comment] The promise and the reality of targeted next-generation sequencing for drug-resistant tuberculosis detection
The ability to sequence the Mycobacterium tuberculosis genome represents the biggest microbiological advance since Robert Koch identified it as the causative agent of tuberculosis. Routine whole-genome sequencing (WGS) has been implemented in some coun...
[Newsdesk] Serious threat of antimicrobial resistance in Ukraine
In September, 2024, WHO warned of the serious threat of antimicrobial resistance in Ukraine as Russia's invasion continues. Ed Holt reports.