Interference between passive immunity and vaccine response is clinically significant and might affect the implementation of next-generation CSP-based vaccines for young infants and mothers as well as passive immunisation with human monoclonal antibodies.

Boosting mRNA-immunised adults with ARCT-2301 induced superior immunogenicity compared with Comirnaty BA.4-5 against both Wuhan-Hu-1 and omicron BA.4/5 variant COVID-19, and elicited a higher response against omicron XBB.1.5. Both vaccines had similar ...

In 2021, RTS,S/AS01 became the first human parasite vaccine approved by WHO for the prevention of Plasmodium falciparum malaria in children from 5 months of age living in regions with moderate to high transmission.1 The vaccine consists of the NANP-rep...

mRNA-based vaccines, as shown by licensed COVID-19 vaccines, are immunogenic and can offer protection from severe disease with high efficacy.1,2 With the recent approval of a novel mRNA-based vaccine against human respiratory syncytial virus (mRESVIA; ...

As for much of the world, COVID-19 has left an undeniable and long-lasting path of destruction throughout South Asia. Every country had its own response and consequently its own experience with the pandemic. Unfortunately, those worst affected are ofte...

How do we choose who to trust? During the unsettling COVID-19 pandemic, we all made decisions about who we could trust to keep us safe: a risk-weighing action that weighed up the people and systems we trusted to protect our health. In COVID-19 response...

Pins and needles, the latest play by Scottish writer Rob Drummond, takes on the incendiary topic of vaccine hesitancy. It seemingly draws on interviews conducted by Drummond, alongside excerpts from the writings of Edward Jenner (1749–1823), the pionee...

Oda Y, Kumagai Y, Kanai M, et al. 12-month persistence of immune responses to self-amplifying mRNA COVID-19 vaccines: ARCT-154 versus BNT162b2 vaccine. Lancet Infect Dis 2024; published online Oct 7. https://doi.org/10.1016/S1473-3099(24)00615-7—In thi...

Oda Y, Kumagai Y, Kanai M, et al. 12-month persistence of immune responses to self-amplifying mRNA COVID-19 vaccines: ARCT-154 versus BNT162b2 vaccine. Lancet Infect Dis 2024; published online Oct 7. https://doi.org/10.1016/S1473-3099(24)00615-7—In thi...

Brickley EB, Miranda-Filho DdB, Ximenes RAdA, on behalf of the MERG, ZBC-Consortium, and LIFE Zika Study members. Preparing for the rapid research response to the possible vertical transmission of Oropouche virus: lessons from a decade of congenital Zi...

Brickley EB, Miranda-Filho DdB, Ximenes RAdA, on behalf of the MERG, ZBC-Consortium, and LIFE Zika Study members. Preparing for the rapid research response to the possible vertical transmission of Oropouche virus: lessons from a decade of congenital Zi...

This cluster supports that avian C abortus strains can cause human infections and underlines that human-to-human transmission should be considered when tracing the source of such infections.

Stijn Raven and colleagues1 report emerging zoonotic infections caused by avian Chlamydia abortus strains resulting in severe community-acquired pneumonia. The authors describe a Dutch family cluster of community-acquired pneumonia with probable introd...

These findings provide a comprehensive assessment of Oropouche fever in Brazil and contribute to an improved understanding of the 2023–24 Oropouche virus re-emergence. Our exploratory in-vitro data suggest that the increased incidence might be related ...

We detected OROV IgM in six of 68 newborns with microcephaly of unknown cause. One infant who died had OROV RNA and antigen in several tissues, including the brain. The possibility of OROV vertical transmission and potential fetal harm must be investig...

Oropouche virus (OROV), an arbovirus of the Orthobunyavirus genus and Peribunyaviridae family, is a vector-transmitted virus in the Simbu serogroup. Simbuviruses have long had importance in veterinary medicine because of their ability to induce severe ...