Adding ivermectin to dihydroartemisinin–piperaquine MDA had no additional effect on reducing malaria prevalence or vector parity in this setting. The intervention was well tolerated. To our knowledge, this trial is the first to be designed to assess wh...
Refugees and asylum seekers might have an increased risk of antimicrobial resistance (AMR) carriage or infection due to several factors, with conflict and war known to accelerate the spread of AMR. However, data are scarce on prevalence and risk factor...
Doxycycline post-exposure prophylaxis (DoxyPEP), often known as a morning-after pill, can help prevent bacterial sexually transmitted infections (STIs). Taking 200 mg of doxycycline within the 72 h after condomless sex has been shown to reduce syphilis...
New licensing agreements for production of a generic version of HIV drug lenacapavir have been heavily criticised by activists who say they are too restrictive. Ed Holt reports.
Crimean–Congo haemorrhagic fever (CCHF) is a widely distributed and potentially fatal tick-borne viral disease with no licensed specific treatments or vaccines. In 2019, WHO published an advanced draft of a research and development roadmap for CCHF tha...
The SARS-CoV-2 KP.3.1.1 lineage is currently the dominating lineage on several continents. In parallel, the XEC lineage, a recombinant of KS.1.1 and KP.3.3,1 is rapidly gaining prevalence in Europe and North America, and is on track to become the next ...
Awareness of YEZV infection is important and clinicians should consider the virus when diagnosing patients with suitable symptoms.
Yezo virus is a causative agent of tick-borne febrile illness first recognized in Hokkaido, the northernmost island of Japan, in 2019 (reported in 2021). Yezo virus is a member of the genus Orthonairovirus and family Nairoviridae, and is phylogenetical...
Heil EL, McCreary EK. REVISITing treatment of metallo-β-lactamases. Lancet Infect Dis 2024; published online Oct 7. https://doi.org/10.1016/S1473-3099(24)00561-9—In this Comment, two corrections have been made. The correct treatment difference for clin...
Invasive meningococcal disease continues to be a life-threatening infectious disease with rapid clinical progression and a case-fatality rate of up to 20% in young adults.1 In 2019, an estimated 2·51 million cases of meningitis occurred globally, with ...
NmCV-5 was non-inferior to MenACWY-D in terms of seroresponse and GMTs, was safe, and demonstrated lot-to-lot consistency. NmCV-5 is prequalified by WHO and was rolled out in the African meningitis belt in April, 2024.
The SARS-CoV-2 JN.1 (BA.2.86.1.1) variant, arising from BA.2.86.1 with spike protein (S) substitution S:L455S, outcompeted the previously predominant XBB lineages by the beginning of 2024.1 Subsequently, JN.1 subvariants including KP.2 (JN.1.11.1.2) an...
Disease associated with Cladophialophora bantiana infection is uncommon but can be characterised by severe and life-threatening CNS involvement. Diagnosis is challenging due to both the infection's rarity and non-specific clinical presentation, which c...
Disease associated with Cladophialophora bantiana infection is uncommon but can be characterised by severe and life-threatening CNS involvement. Diagnosis is challenging due to both the infection's rarity and non-specific clinical presentation, which c...
Babiker A, Warner S, Li X, et al. Adjunctive linezolid versus clindamycin for toxin inhibition in β-lactam-treated patients with invasive group A streptococcal infections in 195 US hospitals from 2016 to 2021: a retrospective cohort study with target t...
Babiker A, Warner S, Li X, et al. Adjunctive linezolid versus clindamycin for toxin inhibition in β-lactam-treated patients with invasive group A streptococcal infections in 195 US hospitals from 2016 to 2021: a retrospective cohort study with target t...